Difference between revisions of "Juxtaglomerular cell tumour"
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'''Juxtaglomerular cell tumour''', abbreviated '''JCT''', is a rare [[kidney tumour]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = juxtaglomerular tumour, reninoma | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[metanephric adenoma]], [[papillary renal cell carcinoma]], [[epithelioid angiomyolipoma]], [[chromophobe renal cell carcinoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[kidney tumours]]'' | |||
| Assdx = [[hypertension]] | |||
| Syndromes = | |||
| Clinicalhx = usu. young adult or adolescent | |||
| Signs = [[hypertension]] | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = increased plasma renin | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign (???) | |||
| Other = | |||
| ClinDDx = other causes of [[hypertension]] | |||
| Tx = surgery | |||
}} | |||
'''Juxtaglomerular cell tumour''', abbreviated '''JCT''', is a rare [[kidney tumour]] associated with [[hypertension]] and typically seen in adolescents or young adults. | |||
It is also known as '''juxtaglomerular tumour''' and '''reninoma'''.<ref name=pmid18192852>{{Cite journal | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref> | It is also known as '''juxtaglomerular tumour''' and '''reninoma'''.<ref name=pmid18192852>{{Cite journal | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref> | ||
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*Rare. | *Rare. | ||
*Etiology: increased renin. | *Etiology: increased renin. | ||
*Typically adolescents or young adults.<ref name=pmid21871063/> | |||
Clinical:<ref name=pmid18192852>{{Cite journal | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref> | Clinical:<ref name=pmid18192852>{{Cite journal | last1 = Wong | first1 = L. | last2 = Hsu | first2 = TH. | last3 = Perlroth | first3 = MG. | last4 = Hofmann | first4 = LV. | last5 = Haynes | first5 = CM. | last6 = Katznelson | first6 = L. | title = Reninoma: case report and literature review. | journal = J Hypertens | volume = 26 | issue = 2 | pages = 368-73 | month = Feb | year = 2008 | doi = 10.1097/HJH.0b013e3282f283f3 | PMID = 18192852 }}</ref> | ||
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*Perinuclear halo. | *Perinuclear halo. | ||
DDx: | DDx:<ref name=pmid21871063/> | ||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant. | *[[Metanephric adenoma]]. | ||
*[[Papillary RCC]]. | |||
*[[Epithelioid angiomyolipoma]]. | |||
*[[Chromophobe renal cell carcinoma]], eosinophilic variant.{{fact}} | |||
Note - some similarities with: | |||
*[[Solitary fibrous tumour]]. | |||
*[[Glomus tumour]]. | |||
===Images=== | ===Images=== | ||
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==Stains== | ==Stains== | ||
Cytoplasmic granules.<ref name=pmid436071>{{Cite journal | last1 = Hanna | first1 = W. | last2 = Tepperman | first2 = B. | last3 = Logan | first3 = AG. | last4 = Robinette | first4 = MA. | last5 = Colapinto | first5 = R. | last6 = Phillips | first6 = MJ. | title = Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension. | journal = Can Med Assoc J | volume = 120 | issue = 8 | pages = 957-9 | month = Apr | year = 1979 | doi = | PMID = 436071 PMC = 1819229 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819229/?tool=pubmed }}</ref> | Cytoplasmic granules.<ref name=pmid436071>{{Cite journal | last1 = Hanna | first1 = W. | last2 = Tepperman | first2 = B. | last3 = Logan | first3 = AG. | last4 = Robinette | first4 = MA. | last5 = Colapinto | first5 = R. | last6 = Phillips | first6 = MJ. | title = Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension. | journal = Can Med Assoc J | volume = 120 | issue = 8 | pages = 957-9 | month = Apr | year = 1979 | doi = | PMID = 436071 | PMC = 1819229 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819229/?tool=pubmed }}</ref> | ||
*PAS +ve. | *PAS +ve. | ||
*PASD +ve. | *PASD +ve. | ||
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*Vimentin +ve. | *Vimentin +ve. | ||
*Actin +ve. | *Actin +ve. | ||
*HMB-45 -ve.<ref name=pmid21191395/> | *HMB-45 -ve.<ref name=pmid21191395/> | ||
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*Synaptophysin -ve. | *Synaptophysin -ve. | ||
*NSE -ve. | *NSE -ve. | ||
*CAM5.2 +ve.<ref name=pmid21871063/> ‡ | |||
*CK7 +ve.<ref name=pmid21871063/> ‡ | |||
Note: | |||
*‡ Negative keratin staining reported by Chao ''et al.''.<ref name=pmid21191395>{{Cite journal | last1 = Chao | first1 = CT. | last2 = Chang | first2 = FC. | last3 = Wu | first3 = VC. | last4 = Chen | first4 = JC. | title = Reninoma. | journal = Kidney Int | volume = 79 | issue = 2 | pages = 260 | month = Jan | year = 2011 | doi = 10.1038/ki.2010.445 | PMID = 21191395 }}</ref> | |||
==EM== | ==EM== | ||
Features: | Features: | ||
*Vesicles - contain renin.<ref name=upmc29>URL: [http://path.upmc.edu/cases/case29/micro.html http://path.upmc.edu/cases/case29/micro.html]. Accessed on: 18 December 2011.</ref> | *Vesicles - contain renin.<ref name=upmc29>URL: [http://path.upmc.edu/cases/case29/micro.html http://path.upmc.edu/cases/case29/micro.html]. Accessed on: 18 December 2011.</ref> | ||
==Molecular== | |||
*NOTCH1 rearrangement.<ref>PMID: 37749094</ref> | |||
==See also== | ==See also== | ||
*[[Kidney tumours]]. | *[[Kidney tumours]]. | ||
*[[Renal tumours with eosinophilic cytoplasm]]. | |||
==References== | ==References== |
Latest revision as of 15:15, 26 March 2024
Juxtaglomerular cell tumour | |
---|---|
Diagnosis in short | |
| |
Synonyms | juxtaglomerular tumour, reninoma |
LM DDx | metanephric adenoma, papillary renal cell carcinoma, epithelioid angiomyolipoma, chromophobe renal cell carcinoma |
Site | kidney - see kidney tumours |
| |
Associated Dx | hypertension |
Clinical history | usu. young adult or adolescent |
Signs | hypertension |
Prevalence | very rare |
Blood work | increased plasma renin |
Prognosis | benign (???) |
Clin. DDx | other causes of hypertension |
Treatment | surgery |
Juxtaglomerular cell tumour, abbreviated JCT, is a rare kidney tumour associated with hypertension and typically seen in adolescents or young adults.
It is also known as juxtaglomerular tumour and reninoma.[1]
General
- Rare.
- Etiology: increased renin.
- Typically adolescents or young adults.[2]
Clinical:[1]
- Hypertension.
- Increased aldosterone.
- Causes hypokalemia.
- Increased plasma renin.
Microscopic
Features:[3]
- Polygonal cells.
- Abundant granular, eosinophilic cytoplasm.[4]
- Perinuclear halo.
DDx:[2]
- Metanephric adenoma.
- Papillary RCC.
- Epithelioid angiomyolipoma.
- Chromophobe renal cell carcinoma, eosinophilic variant.[citation needed]
Note - some similarities with:
Images
Stains
Cytoplasmic granules.[4]
- PAS +ve.
- PASD +ve.
IHC
Features:
Others:[2]
- CD31 -ve.
- Desmin -ve.
- S-100 -ve.
- Chromogranin -ve.
- Synaptophysin -ve.
- NSE -ve.
- CAM5.2 +ve.[2] ‡
- CK7 +ve.[2] ‡
Note:
- ‡ Negative keratin staining reported by Chao et al..[3]
EM
Features:
- Vesicles - contain renin.[5]
Molecular
- NOTCH1 rearrangement.[6]
See also
References
- ↑ 1.0 1.1 Wong, L.; Hsu, TH.; Perlroth, MG.; Hofmann, LV.; Haynes, CM.; Katznelson, L. (Feb 2008). "Reninoma: case report and literature review.". J Hypertens 26 (2): 368-73. doi:10.1097/HJH.0b013e3282f283f3. PMID 18192852.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Kuroda, N.; Gotoda, H.; Ohe, C.; Mikami, S.; Inoue, K.; Nagashima, Y.; Petersson, F.; Alvarado-Cabrero, I. et al. (2011). "Review of juxtaglomerular cell tumor with focus on pathobiological aspect.". Diagn Pathol 6: 80. doi:10.1186/1746-1596-6-80. PMID 21871063.
- ↑ 3.0 3.1 3.2 3.3 Chao, CT.; Chang, FC.; Wu, VC.; Chen, JC. (Jan 2011). "Reninoma.". Kidney Int 79 (2): 260. doi:10.1038/ki.2010.445. PMID 21191395.
- ↑ 4.0 4.1 Hanna, W.; Tepperman, B.; Logan, AG.; Robinette, MA.; Colapinto, R.; Phillips, MJ. (Apr 1979). "Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension.". Can Med Assoc J 120 (8): 957-9. PMC 1819229. PMID 436071. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819229/.
- ↑ URL: http://path.upmc.edu/cases/case29/micro.html. Accessed on: 18 December 2011.
- ↑ PMID: 37749094