Difference between revisions of "TFE3"

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{{ Infobox immunostain
| Name      = {{PAGENAME}}
| Image      =
| Width      =
| Caption    =
| Abbrev    =
| Synonyms  =
| Similar    =
| Clones    =     
| Use        = screen to detect TFE3 rearrangements
| Subspecial = [[urologic pathology]], [[soft tissue pathology]] 
| Pattern    = nuclear stain
| Positive  = [[Xp11.2 translocation carcinoma]], [[alveolar soft part sarcoma]]
| Negative  = normal tissues
| Other      =
}}
'''TFE3''' is an [[immunostain]] used in [[uropathology]] and [[soft tissue pathology]].
'''TFE3''' is an [[immunostain]] used in [[uropathology]] and [[soft tissue pathology]].
The reliability of the immunostain for detecting TFE3 rearrangments has been questioned by at least one study.<ref name=pmid30851332>{{cite journal |vauthors=Sharain RF, Gown AM, Greipp PT, Folpe AL |title=Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, 2-laboratory study |journal=Hum Pathol |volume=87 |issue= |pages=65–74 |date=May 2019 |pmid=30851332 |doi=10.1016/j.humpath.2019.02.008 |url=}}</ref>


==Negative==
==Negative==
*Normal tissue.<ref>URL: [http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf]. Accessed on: September 11, 2017.</ref>
*Normal tissue.<ref>URL: [http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf]. Accessed on: September 11, 2017.</ref>
**Staining in normal tissue described as "extremely rare" - negative in adrenal gland, breast, colon, gallbaldder, lymph node, liver, prostate and skin.<ref name=pmid12766578>{{Cite journal  | last1 = Argani | first1 = P. | last2 = Lal | first2 = P. | last3 = Hutchinson | first3 = B. | last4 = Lui | first4 = MY. | last5 = Reuter | first5 = VE. | last6 = Ladanyi | first6 = M. | title = Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay. | journal = Am J Surg Pathol | volume = 27 | issue = 6 | pages = 750-61 | month = Jun | year = 2003 | doi =  | PMID = 12766578 }}</ref>


==Positive==
==Positive==
*[[Xp11.2 translocation carcinoma]].
*[[Xp11.2 translocation carcinoma]].
*[[Alveolar soft part sarcoma]].
*[[Alveolar soft part sarcoma]].
* YAP-TFE3 translocated [[epithelioid hemangioendothelioma]]
*[[Epithelioid angiomyolipoma]].
*[[Granular cell tumour]].<ref>{{cite journal |authors=Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM |title=Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study |journal=Hum. Pathol. |volume=45 |issue=5 |pages=1039–44 |date=May 2014 |pmid=24746209 |doi=10.1016/j.humpath.2013.12.021 |url=}}</ref>


==See also==
==See also==

Latest revision as of 03:49, 16 October 2023

TFE3
Immunostain in short
Use screen to detect TFE3 rearrangements
Subspeciality urologic pathology, soft tissue pathology
Normal staining pattern nuclear stain
Positive Xp11.2 translocation carcinoma, alveolar soft part sarcoma
Negative normal tissues

TFE3 is an immunostain used in uropathology and soft tissue pathology.

The reliability of the immunostain for detecting TFE3 rearrangments has been questioned by at least one study.[1]

Negative

  • Normal tissue.[2]
    • Staining in normal tissue described as "extremely rare" - negative in adrenal gland, breast, colon, gallbaldder, lymph node, liver, prostate and skin.[3]

Positive

See also

References

  1. "Immunohistochemistry for TFE3 lacks specificity and sensitivity in the diagnosis of TFE3-rearranged neoplasms: a comparative, 2-laboratory study". Hum Pathol 87: 65–74. May 2019. doi:10.1016/j.humpath.2019.02.008. PMID 30851332.
  2. URL: http://www.ihcworld.com/_newsletter/2003/focus_jul_2003.pdf. Accessed on: September 11, 2017.
  3. Argani, P.; Lal, P.; Hutchinson, B.; Lui, MY.; Reuter, VE.; Ladanyi, M. (Jun 2003). "Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay.". Am J Surg Pathol 27 (6): 750-61. PMID 12766578.
  4. Chamberlain BK, McClain CM, Gonzalez RS, Coffin CM, Cates JM (May 2014). "Alveolar soft part sarcoma and granular cell tumor: an immunohistochemical comparison study". Hum. Pathol. 45 (5): 1039–44. doi:10.1016/j.humpath.2013.12.021. PMID 24746209.