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→Uncommon Astrocytomas: link
Jensflorian (talk | contribs) (Update on categories) |
Jensflorian (talk | contribs) (→Uncommon Astrocytomas: link) |
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*[[Astrocytoma, IDH-mutant]]. | *[[Astrocytoma, IDH-mutant]]. | ||
*[[Glioblastoma]], IDH wildtype. | *[[Glioblastoma]], IDH wildtype. | ||
*High-grade astrocytoma with piloid features. | *[[High-grade astrocytoma with piloid features]]. | ||
*[[Pleomorphic xanthroastrocytoma]]. | *[[Pleomorphic xanthroastrocytoma]]. | ||
*[[Subependymal giant cell astrocytoma]]. | *[[Subependymal giant cell astrocytoma]]. | ||
* | *Chordoid glioma. | ||
=Pediatric-type astrocytomas= | =Pediatric-type astrocytomas= | ||
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*[[Pediatric-type diffuse high-grade glioma]]. | *[[Pediatric-type diffuse high-grade glioma]]. | ||
*[[Pediatric-type diffuse low-grade glioma]]. | *[[Pediatric-type diffuse low-grade glioma]]. | ||
*[[Astroblastoma]]. | *[[Astroblastoma]], MN1-altered. | ||
=Diffuse growing astrocytomas= | |||
*[[Astrocytoma, IDH-mutant]]. | |||
*[[Glioblastoma]], IDH wildtype. | |||
*[[Diffuse midline glioma, H3 K27-altered]]. | |||
*[[Diffuse hemispheric glioma, H3 G34-mutant]]. | |||
*[[Diffuse astrocytoma, MYB- or MYBL-altered]]. | |||
*Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype. | |||
*Angiocentric glioma. | |||
*Diffuse low-grade glioma, MAPK pathway-altered. | |||
=Circumscribed astrocytomas= | |||
*[[Pilocytic astrocytoma]]. | |||
*[[High-grade astrocytoma with piloid features]]. | |||
*[[Pleomorphic xanthroastrocytoma]]. | |||
*[[Subependymal giant cell astrocytoma]]. | |||
*[[Chordoid glioma]]. | |||
*[[Astroblastoma]], MN1-altered. | |||
=Common Astrocytomas= | =Common Astrocytomas= | ||
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* Astrocytoma, IDH mutant are less common than glioblastoma. | * Astrocytoma, IDH mutant are less common than glioblastoma. | ||
* Grade 2-4 depends on histological and molecular criteria: | * Grade 2-4 depends on histological and molecular criteria: | ||
{{Main|Astrocytoma, IDH-mutant}} | |||
=== Astrocytoma, IDH mutant grade 2=== | === Astrocytoma, IDH mutant grade 2=== | ||
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* Typically seen in adults. | * Typically seen in adults. | ||
* Usually shows progression to astrocytoma IDH mutant, grade 4. | * Usually shows progression to astrocytoma IDH mutant, grade 4. | ||
===Astrocytoma, IDH mutant grade 3=== | ===Astrocytoma, IDH mutant grade 3=== | ||
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* Increased cellularity, cell atypia and mitotic activity. | * Increased cellularity, cell atypia and mitotic activity. | ||
* Lacks endothelial proliferations and necrosis of glioblastoma. | * Lacks endothelial proliferations and necrosis of glioblastoma. | ||
===Astrocytoma, IDH mutant grade 4=== | ===Astrocytoma, IDH mutant grade 4=== | ||
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{{Main|Diffuse hemispheric glioma, H3 G34-mutant}} | {{Main|Diffuse hemispheric glioma, H3 G34-mutant}} | ||
==High-grade astrocytoma with piloid features== | |||
* Frequent in posterior fossa (75%). | |||
* 1-3% of all brain tumors. | |||
* Histology may resemble Glionblastoma or Pleomorphic xanthoastrocytoma. | |||
* Tumor is enriched for piloid cell processes. | |||
* ATRX nuclear loss is frequent. | |||
* Usu. MAPK-pathway alterations + CDKN2A homozygous deletion. | |||
* Distinct methylation profile. | |||
{{Main|High-grade astrocytoma with piloid features}} | |||
==Gliomatosis cerebri== | ==Gliomatosis cerebri== | ||