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Difference between revisions of "Squamous cell carcinoma of the skin"
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Squamous cell carcinoma of the skin (view source)
Revision as of 16:19, 7 June 2022
, 16:19, 7 June 2022→IHC
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| Micro = | | Micro = | ||
| Subtypes = many see ''[[squamous cell carcinoma]]'' | | Subtypes = many see ''[[squamous cell carcinoma]]'' | ||
| LMDDx = [[inverted follicular keratosis]], [[Paget disease of the breast]], [[eccrine carcinoma]], [[atypical fibroxanthoma]], [[malignant melanoma]], [[leiomyosarcoma]], [[basal cell carcinoma]] (for ''[[basaloid squamous cell carcinoma]]'') | | LMDDx = [[inverted follicular keratosis]], [[Paget disease of the breast]], [[eccrine carcinoma]], [[atypical fibroxanthoma]], [[malignant melanoma]], [[leiomyosarcoma]], [[basal cell carcinoma]] (for ''[[basaloid squamous cell carcinoma]]''), [[porocarcinoma]], [[pseudoepitheliomatous hyperplasia]] | ||
| Stains = | | Stains = | ||
| IHC = CK5/6 +ve, p63 +ve, K903 +ve, [[Ber-EP4]] -ve, S-100 -ve | | IHC = CK5/6 +ve, p63 +ve, K903 +ve, [[Ber-EP4]] -ve, S-100 -ve | ||
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*[[Eccrine carcinoma]]. | *[[Eccrine carcinoma]]. | ||
*[[Basal cell carcinoma]] for [[basaloid squamous cell carcinoma]]. | *[[Basal cell carcinoma]] for [[basaloid squamous cell carcinoma]]. | ||
*[[Porocarcinoma]]. | |||
*[[Pseudoepitheliomatous hyperplasia]]. | |||
===Grading=== | ===Grading=== | ||
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*[[Ber-EP4]] usually -ve.<ref name=pmid19187107>{{Cite journal | last1 = Yu | first1 = L. | last2 = Galan | first2 = A. | last3 = McNiff | first3 = JM. | title = Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma. | journal = J Cutan Pathol | volume = 36 | issue = 10 | pages = 1074-176 | month = Oct | year = 2009 | doi = 10.1111/j.1600-0560.2008.01223.x | PMID = 19187107 }}</ref> | *[[Ber-EP4]] usually -ve.<ref name=pmid19187107>{{Cite journal | last1 = Yu | first1 = L. | last2 = Galan | first2 = A. | last3 = McNiff | first3 = JM. | title = Caveats in BerEP4 staining to differentiate basal and squamous cell carcinoma. | journal = J Cutan Pathol | volume = 36 | issue = 10 | pages = 1074-176 | month = Oct | year = 2009 | doi = 10.1111/j.1600-0560.2008.01223.x | PMID = 19187107 }}</ref> | ||
** Usually +ve in [[BCC]]. | ** Usually +ve in [[BCC]]. | ||
*EMA +ve (~83% +ve).<ref name=pmid27039776>{{cite journal |authors=Ramezani M, Mohamadzaheri E, Khazaei S, Najafi F, Vaisi-Raygani A, Rahbar M, Sadeghi M |title=Comparison of EMA,CEA, CD10 and Bcl-2 Biomarkers by Immunohistochemistry in Squamous Cell Carcinoma and Basal Cell Carcinoma of the Skin |journal=Asian Pac J Cancer Prev |volume=17 |issue=3 |pages=1379–83 |date=2016 |pmid=27039776 |doi=10.7314/apjcp.2016.17.3.1379 |url=}}</ref> | |||
** Usually -ve in BCC. | |||
==Staging== | ==Staging== | ||
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|- | |- | ||
| T2 | | T2 | ||
| >2 cm and less than two high-risk factors ''or'' two | | >2 cm and less than two high-risk factors ''or'' two or more high-risk factors | ||
| see ''microscopic'' for list of high-risk factors | | see ''microscopic'' for list of high-risk factors | ||
|- | |- | ||