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Diagnosis in short

Porocarcinoma. H&E stain.

basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, verruca vulgaris,

adenocarcinoma, malignant melanoma
IHC CD117 +ve
Site skin - typically head & neck

Prevalence very rare
Prognosis poor
Treatment surgical excision

Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour.[1]

It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma.[2]


  • Malignant counterpart of poroma.[3]
  • Very rare ~ most papers are case reports.[4]

Clinical features - based on meta-analysis of 453 cases:[1]

  • No predominance males versus females.
  • Aggressive behaviour >30% of cases have metastases at presentation - typically to lymph nodes.


  • Surgery,


  • Mass or nodule - typically head and neck (40% of cases) or lower extremity (34% of cases).[1]



  • Ductal/eccrine differentiation:[2]
    • Intracytoplasmic lumens.
    • Multicellular ducts with thin esoinophilic layer.
    • Lack granular cells and lack decapitated lumens - features of apocrine differentiation.
  • Features of malignancy:[2]
  • +/-Squamous differentiation.
  • +/-Basaloid differentiation.






See also


  1. 1.0 1.1 1.2 Salih, AM.; Kakamad, FH.; Baba, HO.; Salih, RQ.; Hawbash, MR.; Mohammed, SH.; Othman, S.; Saeed, YA. et al. (Aug 2017). "Porocarcinoma; presentation and management, a meta-analysis of 453 cases.". Ann Med Surg (Lond) 20: 74-79. doi:10.1016/j.amsu.2017.06.027. PMID 28721214.
  2. 2.0 2.1 2.2 Luz, Mde A.; Ogata, DC.; Montenegro, MF.; Biasi, LJ.; Ribeiro, LC. (Jul 2010). "Eccrine porocarcinoma (malignant eccrine poroma): a series of eight challenging cases.". Clinics (Sao Paulo) 65 (7): 739-42. doi:10.1590/S1807-59322010000700014. PMID 20668633.
  3. 3.0 3.1 3.2 Abarzúa, Á.; Álvarez-Véliz, S.; Moll-Manzur, C.. "Concomitant poroma and porocarcinoma.". An Bras Dermatol 92 (4): 550-552. doi:10.1590/abd1806-4841.20175719. PMID 28954110.
  4. Riera-Leal, L.; Guevara-Gutiérrez, E.; Barrientos-García, JG.; Madrigal-Kasem, R.; Briseño-Rodríguez, G.; Tlacuilo-Parra, A. (2015). "Eccrine porocarcinoma: epidemiologic and histopathologic characteristics.". Int J Dermatol 54 (5): 580-6. doi:10.1111/ijd.12714. PMID 25515648.
  5. Kurashige, Y.; Minemura, T.; Nagatani, T. (2013). "Eccrine porocarcinoma: clinical and pathological report of eight cases.". Case Rep Dermatol 5 (3): 259-66. doi:10.1159/000355606. PMID 24403888.
  6. Goto, K.; Takai, T.; Fukumoto, T.; Anan, T.; Kimura, T.; Ansai, S.; Oshitani, Y.; Murata, Y. et al. (Mar 2016). "CD117 (KIT) is a useful immunohistochemical marker for differentiating porocarcinoma from squamous cell carcinoma.". J Cutan Pathol 43 (3): 219-26. doi:10.1111/cup.12632. PMID 26449497.