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Difference between revisions of "Invasive lobular carcinoma"
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Invasive lobular carcinoma (view source)
Revision as of 19:26, 20 December 2021
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| LMDDx = [[invasive ductal carcinoma of the breast]] with lobular features, poorly differentiated carcinoma, [[LCIS]] | | LMDDx = [[invasive ductal carcinoma of the breast]] with lobular features, poorly differentiated carcinoma, [[LCIS]] | ||
| Stains = | | Stains = | ||
| IHC = usu. ER and PR +ve, HER2 -ve, CK7 +ve | | IHC = [[E-cadherin]] -ve, usu. ER and PR +ve, HER2 -ve, [[CK7]] +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| IF = | | IF = | ||
| Gross = | | Gross = | ||
| Grossing = | | Grossing = [[breast grossing]] | ||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | | Site = [[breast]] - see ''[[invasive breast cancer]]'' | ||
| Assdx = | | Assdx = | ||
| Syndromes = hereditary diffuse gastric cancer | | Syndromes = [[hereditary diffuse gastric cancer]] | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = | | Signs = | ||
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*Poorly differentiated carcinoma. | *Poorly differentiated carcinoma. | ||
*[[LCIS]]. | *[[LCIS]]. | ||
*[[Malignant melanoma]]. | |||
===Subclassification=== | |||
*Classic lobular carcinoma. | |||
**Low nuclear grade - NO significant variation of nucleus size. | |||
*Pleomorphic lobular carcinoma. | |||
**Significant nuclear atypia. | |||
Note: | |||
*Some pathologist grade lobular carcinoma like other types and avoid the term "pleomorphic lobular carcinoma."<ref>MUA. Jan 22, 2009.</ref> | |||
Other variants: | |||
*Histiocytoid.<ref name=pmid21398688>{{Cite journal | last1 = Tan | first1 = PH. | last2 = Harada | first2 = O. | last3 = Thike | first3 = AA. | last4 = Tse | first4 = GM. | title = Histiocytoid breast carcinoma: an enigmatic lobular entity. | journal = J Clin Pathol | volume = 64 | issue = 8 | pages = 654-9 | month = Aug | year = 2011 | doi = 10.1136/jcp.2011.088930 | PMID = 21398688 }}</ref> | |||
===Images=== | ===Images=== | ||
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Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron) | Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - high mag. (WC/Nephron) | ||
Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron) | Image:Lobular_carcinoma_-_high_mag.jpg | Lobular carcinoma - very high mag. (WC/Nephron) | ||
</gallery> | |||
<gallery> | |||
Image:Breast_invasive_lobular_carcinoma_%281%29.jpg | Lobular carcinoma - 1 (WC) | |||
Image:Breast_invasive_lobular_carcinoma_%282%29.jpg | Lobular carcinoma - 2 (WC) | |||
</gallery> | </gallery> | ||
==IHC== | |||
*[ | Features: | ||
*[[E-cadherin]] -ve. | |||
*ER and PR +ve. | |||
*HER2 -ve. | |||
* | *CK7 +ve. | ||
* | |||
* | |||
Others: | |||
* | *CK20 -ve. | ||
*Beta-catenin -ve/+ve (~46% completely negative<ref name=pmid11237489>{{cite journal |authors=Karayiannakis AJ, Nakopoulou L, Gakiopoulou H, Keramopoulos A, Davaris PS, Pignatelli M |title=Expression patterns of beta-catenin in in situ and invasive breast cancer |journal=Eur J Surg Oncol |volume=27 |issue=1 |pages=31–6 |date=February 2001 |pmid=11237489 |doi=10.1053/ejso.1999.1017 |url=}}</ref>). | |||
==See also== | ==See also== | ||
*[[Invasive breast cancer]]. | *[[Invasive breast cancer]]. | ||
*[[Signet ring cell carcinoma]]. | |||
==References== | ==References== | ||