Difference between revisions of "Smoking-related interstitial fibrosis"
Jump to navigation
Jump to search
| Line 37: | Line 37: | ||
Clinical: | Clinical: | ||
*Much better prognosis than UIP with emphysema - five year survival 86% (SRIF) versus 41% (UIP).<ref name=pmid27611866>{{Cite journal | last1 = Chae | first1 = KJ. | last2 = Jin | first2 = GY. | last3 = Jung | first3 = HN. | last4 = Kwon | first4 = KS. | last5 = Choi | first5 = H. | last6 = Lee | first6 = YC. | last7 = Chung | first7 = MJ. | last8 = Park | first8 = HS. | title = Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. | journal = PLoS One | volume = 11 | issue = 9 | pages = e0162231 | month = | year = 2016 | doi = 10.1371/journal.pone.0162231 | PMID = 27611866 }}</ref> | *Much better prognosis than [[usual interstitial pneumonia]] (UIP) with [[emphysema]] - five year survival 86% (SRIF) versus 41% (UIP).<ref name=pmid27611866>{{Cite journal | last1 = Chae | first1 = KJ. | last2 = Jin | first2 = GY. | last3 = Jung | first3 = HN. | last4 = Kwon | first4 = KS. | last5 = Choi | first5 = H. | last6 = Lee | first6 = YC. | last7 = Chung | first7 = MJ. | last8 = Park | first8 = HS. | title = Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. | journal = PLoS One | volume = 11 | issue = 9 | pages = e0162231 | month = | year = 2016 | doi = 10.1371/journal.pone.0162231 | PMID = 27611866 }}</ref> | ||
==Gross== | ==Gross== | ||
Latest revision as of 17:16, 8 May 2019
| Smoking-related interstitial fibrosis | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | septal thickening of alveoli with thick collagen bundles (described as "ropy") and hyperplastic smooth muscle fibres; minimal inflammation |
| LM DDx | usual interstitial pneumonia |
| Gross | subpleural and centrilobular predominance |
| Site | lung |
|
| |
| Associated Dx | emphysema, respiratory bronchiolitis |
| Clinical history | smoking |
| Prognosis | benign, better than UIP |
Smoking-related interstitial fibrosis, abbreviated SRIF, is a benign pauci-inflammatory scarring associated with smoking.
General
- Associated with emphysema and respiratory bronchiolitis.[1]
Clinical:
- Much better prognosis than usual interstitial pneumonia (UIP) with emphysema - five year survival 86% (SRIF) versus 41% (UIP).[2]
Gross
- Subpleural and centrilobular predominance.[1]
Microscopic
Features:[1]
- Septal thickening of alveoli with:
- Thick collagen bundles - may be described as "ropy".[3]
- Hyperplastic smooth muscle fibres.
- Minimal inflammation.
DDx:
- Usual interstitial pneumonia - has inflammation.
Images
See also
References
- ↑ 1.0 1.1 1.2 1.3 Katzenstein, AL. (Jan 2012). "Smoking-related interstitial fibrosis (SRIF), pathogenesis and treatment of usual interstitial pneumonia (UIP), and transbronchial biopsy in UIP.". Mod Pathol 25 Suppl 1: S68-78. doi:10.1038/modpathol.2011.154. PMID 22214972.
- ↑ 2.0 2.1 Chae, KJ.; Jin, GY.; Jung, HN.; Kwon, KS.; Choi, H.; Lee, YC.; Chung, MJ.; Park, HS. (2016). "Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases.". PLoS One 11 (9): e0162231. doi:10.1371/journal.pone.0162231. PMID 27611866.
- ↑ 3.0 3.1 Primiani, A.; Dias-Santagata, D.; Iafrate, AJ.; Kradin, RL. (2014). "Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis.". Int J Chron Obstruct Pulmon Dis 9: 525-31. doi:10.2147/COPD.S61932. PMID 24920890.