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Difference between revisions of "Pneumocytoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Pneumocytoma - alt -- intermed mag.jpg | |||
| Width = | |||
| Caption = Pneumocytoma. [[H&E stain]]. (WC/Nephron) | |||
| Synonyms = sclerosing hemangioma, benign pneumocytoma | |||
| Micro = mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas | |||
| Subtypes = | |||
| LMDDx = [[carcinoid tumour]], papillary pattern [[lung adenocarcinoma]], metastatic [[papillary thyroid carcinoma]] | |||
| Stains = | |||
| IHC = TTF-1 +ve, Ki-67 +ve membranous pattern, PR +ve, CD56 -ve, CD34 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = lung - see ''[[lung tumours]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = typical patient - female 40s | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare <= 1% of lung tumours | |||
| Bloodwork = | |||
| Rads = slow growth/no growth, typically peripheral location | |||
| Endoscopy = | |||
| Prognosis = benign, case reports of mets | |||
| Other = | |||
| ClinDDx = other [[lung tumours]] | |||
| Tx = usually excision, may be followed | |||
}} | |||
'''Pneumocytoma''' is a rare [[lung tumour]] that is typically benign. It is also known as '''sclerosing pneumocytoma'''.<ref name=pmid6291188>{{Cite journal | last1 = Chan | first1 = KW. | last2 = Gibbs | first2 = AR. | last3 = Lo | first3 = WS. | last4 = Newman | first4 = GR. | title = Benign sclerosing pneumocytoma of lung (sclerosing haemangioma). | journal = Thorax | volume = 37 | issue = 6 | pages = 404-12 | month = Jun | year = 1982 | doi = | PMID = 6291188 }}</ref><ref name=pmid23380035/> | '''Pneumocytoma''' is a rare [[lung tumour]] that is typically benign. It is also known as '''sclerosing pneumocytoma'''.<ref name=pmid6291188>{{Cite journal | last1 = Chan | first1 = KW. | last2 = Gibbs | first2 = AR. | last3 = Lo | first3 = WS. | last4 = Newman | first4 = GR. | title = Benign sclerosing pneumocytoma of lung (sclerosing haemangioma). | journal = Thorax | volume = 37 | issue = 6 | pages = 404-12 | month = Jun | year = 1982 | doi = | PMID = 6291188 }}</ref><ref name=pmid23380035/> | ||
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*Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | *Progesterone-receptor positive stromal cells.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | ||
*Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal | last1 = Salemis | first1 = NS. | last2 = Seretis | first2 = C. | last3 = Nakos | first3 = G. | last4 = Kantounakis | first4 = I. | last5 = Stoumpos | first5 = C. | last6 = Spiliopoulos | first6 = K. | title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. | journal = Breast Dis | volume = 34 | issue = 2 | pages = 61-5 | month = Jan | year = 2013 | doi = 10.3233/BD-130352 | PMID = 23838116 }}</ref> | *Rare - 0.2% to 1% of lung tumours.<ref name=pmid23838116>{{Cite journal | last1 = Salemis | first1 = NS. | last2 = Seretis | first2 = C. | last3 = Nakos | first3 = G. | last4 = Kantounakis | first4 = I. | last5 = Stoumpos | first5 = C. | last6 = Spiliopoulos | first6 = K. | title = Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature. | journal = Breast Dis | volume = 34 | issue = 2 | pages = 61-5 | month = Jan | year = 2013 | doi = 10.3233/BD-130352 | PMID = 23838116 }}</ref> | ||
**One large series had 100 cases.<ref name=pmid10895813>{{Cite journal | last1 = Devouassoux-Shisheboran | first1 = M. | last2 = Hayashi | first2 = T. | last3 = Linnoila | first3 = RI. | last4 = Koss | first4 = MN. | last5 = Travis | first5 = WD. | title = A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies: TTF-1 is expressed in both round and surface cells, suggesting an origin from primitive respiratory epithelium. | journal = Am J Surg Pathol | volume = 24 | issue = 7 | pages = 906-16 | month = Jul | year = 2000 | doi = | PMID = 10895813 }}</ref> | |||
Management: | Management: | ||
| Line 18: | Line 51: | ||
*Peripheral, solitary. | *Peripheral, solitary. | ||
*Well-circumscribed. | *Well-circumscribed. | ||
*Classically hemorrhagic. | |||
==Microscopic== | ==Microscopic== | ||
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DDx:<ref>URL: [http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf]. Accessed on: 17 June 2010.</ref> | DDx:<ref>URL: [http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf]. Accessed on: 17 June 2010.</ref> | ||
*Papillary | *Papillary pattern: | ||
*[[Neuroendocrine tumour]] (carcinoid). | **Papillary pattern [[lung adenocarcinoma]]. | ||
**Metastatic [[papillary thyroid carcinoma]]. | |||
*Solid pattern: | |||
**[[Neuroendocrine tumour]] (carcinoid). | |||
===Images=== | ===Images=== | ||
--> | <gallery> | ||
Image: Pneumocytoma -- low mag.jpg | Pneumocytoma - low mag. | |||
Image: Pneumocytoma -- intermed mag.jpg | Pneumocytoma - intermed. mag. | |||
Image: Pneumocytoma -- high mag.jpg | Pneumocytoma - high mag. | |||
Image: Pneumocytoma -- very high mag.jpg | Pneumocytoma - very high mag. | |||
Image: Pneumocytoma - alt -- low mag.jpg | Pneumocytoma - low mag. | |||
Image: Pneumocytoma - alt -- intermed mag.jpg | Pneumocytoma - intermed. mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Features:<ref name=pmid10716159>{{Cite journal | last1 = Rodriguez-Soto | first1 = J. | last2 = Colby | first2 = TV. | last3 = Rouse | first3 = RV. | title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. | journal = Am J Surg Pathol | volume = 24 | issue = 3 | pages = 442-50 | month = Mar | year = 2000 | doi = | PMID = 10716159 }}</ref> | Features:<ref name=pmid10716159>{{Cite journal | last1 = Rodriguez-Soto | first1 = J. | last2 = Colby | first2 = TV. | last3 = Rouse | first3 = RV. | title = A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. | journal = Am J Surg Pathol | volume = 24 | issue = 3 | pages = 442-50 | month = Mar | year = 2000 | doi = | PMID = 10716159 }}</ref> | ||
*EMA +ve. | *[[EMA]] +ve. | ||
*PR +ve.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | *PR +ve.<ref name=pmid15731902>{{Cite journal | last1 = Einsfelder | first1 = BM. | last2 = Müller | first2 = KM. | title = ["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung] | journal = Pathologe | volume = 26 | issue = 5 | pages = 367-77 | month = Sep | year = 2005 | doi = 10.1007/s00292-005-0751-8 | PMID = 15731902 }}</ref> | ||
*Ki-67 membranous pattern.<ref name=pmid23030396>{{Cite journal | last1 = Kim | first1 = BH. | last2 = Bae | first2 = YS. | last3 = Kim | first3 = SH. | last4 = Jeong | first4 = HJ. | last5 = Hong | first5 = SW. | last6 = Yoon | first6 = SO. | title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. | journal = APMIS | volume = 121 | issue = 2 | pages = 105-10 | month = Feb | year = 2013 | doi = 10.1111/j.1600-0463.2012.02945.x | PMID = 23030396 }}</ref> | *[[Ki-67]] membranous pattern.<ref name=pmid23030396>{{Cite journal | last1 = Kim | first1 = BH. | last2 = Bae | first2 = YS. | last3 = Kim | first3 = SH. | last4 = Jeong | first4 = HJ. | last5 = Hong | first5 = SW. | last6 = Yoon | first6 = SO. | title = Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas. | journal = APMIS | volume = 121 | issue = 2 | pages = 105-10 | month = Feb | year = 2013 | doi = 10.1111/j.1600-0463.2012.02945.x | PMID = 23030396 }}</ref> | ||
Negative stains:<ref name=pmid10716159/> | Negative stains:<ref name=pmid10716159/> | ||
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*HNF-3 alpha +ve. | *HNF-3 alpha +ve. | ||
*HNF-3 beta +ve. | *HNF-3 beta +ve. | ||
===Images=== | |||
<gallery> | |||
Image: Pneumocytoma - TTF1 -- intermed mag.jpg | Pneumocytoma - TTF-1 - intermed. mag. | |||
Image: Pneumocytoma - TTF1 -- high mag.jpg | Pneumocytoma - TTF-1 - high mag. | |||
Image: Pneumocytoma - Ki67 -- intermed mag.jpg | Pneumocytoma - Ki-67 (membranous) - intermed. mag. | |||
Image: Pneumocytoma - Ki67 -- high mag.jpg | Pneumocytoma - Ki-67 (membranous) - high mag. | |||
</gallery> | |||
==Sign out== | ==Sign out== | ||
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The lesion stains as follows: | The lesion stains as follows: | ||
POSITIVE: Ki-67 (membranous pattern), TTF-1, PR. | POSITIVE: Ki-67 (membranous pattern), TTF-1, PR. | ||
NEGATIVE: CD56, p53. | NEGATIVE: CD56, p53, CD34. | ||
</pre> | </pre> | ||
===Micro=== | |||
The sections show lung with thickened alveolar walls containing bland appearing cells with round/oval nuclei without conspicuous nucleoli. Necrosis is absent. | |||
==See also== | ==See also== | ||