Difference between revisions of "Epididymis"
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The '''epididymis''' is a mostly forgotten organ associated with the [[testis]]. It is rarely afflicited by tumours.<ref name=pmid22522502>{{Cite journal | last1 = Yeung | first1 = CH. | last2 = Wang | first2 = K. | last3 = Cooper | first3 = TG. | title = Why are epididymal tumours so rare? | journal = Asian J Androl | volume = 14 | issue = 3 | pages = 465-75 | month = May | year = 2012 | doi = 10.1038/aja.2012.20 | PMID = 22522502 }}</ref> | The '''epididymis''' is a mostly forgotten organ associated with the [[testis]]. It is rarely afflicited by tumours.<ref name=pmid22522502>{{Cite journal | last1 = Yeung | first1 = CH. | last2 = Wang | first2 = K. | last3 = Cooper | first3 = TG. | title = Why are epididymal tumours so rare? | journal = Asian J Androl | volume = 14 | issue = 3 | pages = 465-75 | month = May | year = 2012 | doi = 10.1038/aja.2012.20 | PMID = 22522502 }}</ref> | ||
==Normal histology== | ==Normal histology== | ||
Features: | Features: | ||
*Tubular structures lined by a pseudostratified epithelium with cilia. | *Tubular structures lined by a pseudostratified epithelium with cilia. | ||
Note: | |||
*Epididymis may have clear luminal cells focally. | |||
===Images=== | ===Images=== | ||
| Line 9: | Line 12: | ||
Image:Epididymis_high_mag.jpg |[[Micrograph]] of an epididymis. [[H&E stain]]. | Image:Epididymis_high_mag.jpg |[[Micrograph]] of an epididymis. [[H&E stain]]. | ||
</gallery> | </gallery> | ||
==IHC== | |||
The epididymis' luminal cells stain with: | |||
*CK7 (diffuse). | |||
*p63 (patchy). | |||
Note: | |||
*Clear cells are may be seen; they are NEGATIVE for D2-40, PLAP and CD117. | |||
==Pathology== | ==Pathology== | ||
Latest revision as of 20:22, 30 January 2019
The epididymis is a mostly forgotten organ associated with the testis. It is rarely afflicited by tumours.[1]
Normal histology
Features:
- Tubular structures lined by a pseudostratified epithelium with cilia.
Note:
- Epididymis may have clear luminal cells focally.
Images
Micrograph of an epididymis. H&E stain.
IHC
The epididymis' luminal cells stain with:
- CK7 (diffuse).
- p63 (patchy).
Note:
- Clear cells are may be seen; they are NEGATIVE for D2-40, PLAP and CD117.
Pathology
- Papillary cystadenoma of the epididymis.[2][3]
- Infections - typically afflicit the epididymis before the testis.
- The exception is syphilis; it afflicits the testis first.
- BCG-associated epididymo-orchitis - complicating the treatment of bladder cancer.[4][5]
- Serous cystadenoma of the epididymis.[6]
- Fibrous pseudotumour of the paratesticular region - uncommonly associated with the epididymis.
See also
References
- ↑ Yeung, CH.; Wang, K.; Cooper, TG. (May 2012). "Why are epididymal tumours so rare?". Asian J Androl 14 (3): 465-75. doi:10.1038/aja.2012.20. PMID 22522502.
- ↑ Toutziaris, C.; Kampantais, S.; Perdikis, I.; Gourvas, V.; Laskaridis, L.; Gkagkalidis, K.; Lakis, S.; Ioannidis, S. (2013). "Papillary cystadenoma of epididymis: Is there a need for further investigation in unilateral cases?". Int J Surg Case Rep 4 (7): 616-8. doi:10.1016/j.ijscr.2013.03.038. PMID 23708309.
- ↑ Odrzywolski, KJ.; Mukhopadhyay, S. (Apr 2010). "Papillary cystadenoma of the epididymis.". Arch Pathol Lab Med 134 (4): 630-3. doi:10.1043/1543-2165-134.4.630. PMID 20367315.
- ↑ Parker, SG.; Kommu, SS. (2013). "Post-intravesical BCG epididymo-orchitis: Case report and a review of the literature.". Int J Surg Case Rep 4 (9): 768-70. doi:10.1016/j.ijscr.2013.05.017. PMID 23856256.
- ↑ Bulbul, MA.; Hijaz, A.; Beaini, M.; Araj, GF.; Tawil, A.. "Tuberculous epididymo-orchitis following intravesical BCG for superficial bladder cancer.". J Med Liban 50 (1-2): 67-9. PMID 12841318.
- ↑ Klimis, T.; Vlahos, P.; Kokotas, N.. "Serous cystadenoma of the epididymis of common epithelial ovarian type: case report with an immunohistochemical study.". J BUON 11 (2): 237-40. PMID 17318978.