Difference between revisions of "Myeloproliferative neoplasms"

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MPN vs MDS
m (MPN vs MDS)
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'''Myeloproliferative neoplasms''', also '''myeloproliferative disorders''', are a group of indolent hematologic neoplasms characterized by clonal expansion of pluripotent hematopoietic progenitor.
'''Myeloproliferative neoplasms''', also '''myeloproliferative disorders''', are a group of indolent hematologic neoplasms characterized by clonal expansion of pluripotent hematopoietic progenitor.


These should '''not''' be confused with ''[[myelodysplastic syndromes]]'' (MDS).
These should '''not''' be confused with ''[[myelodysplastic syndromes]]'' (MDS), the main difference is that MPNs produce functional haematological cells detectable on a complete blood count, whereas in MDS, hematopoisis is ineffective and is characterised by cytopenias.


==Grouping==
==Grouping==
They include the following:<ref name=pmid15781101>{{cite journal |author=Baxter EJ, Scott LM, Campbell PJ, ''et al.'' |title=Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders |journal=Lancet |volume=365 |issue=9464 |pages=1054–61 |year=2005 |pmid=15781101 |doi=10.1016/S0140-6736(05)71142-9 |url=}}</ref>
They include the following:<ref name=pmid15781101>{{cite journal |author=Baxter EJ, Scott LM, Campbell PJ, ''et al.'' |title=Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders |journal=Lancet |volume=365 |issue=9464 |pages=1054–61 |year=2005 |pmid=15781101 |doi=10.1016/S0140-6736(05)71142-9 |url=}}</ref>
*Polycythemia vera.
*[[Chronic myeloid leukemia]]
*Essential thrombocythemia.
*[[Polycythemia vera]]
*Idiopathic myelofibrosis.
*[[Essential thrombocythemia]].
*[[Idiopathic myelofibrosis]].


==Clinic==
==Clinic==
* moderate to severe anemia
* moderate to severe anemia (in cases where the erythrocytosis is not a feature)
* pale skin
* pale skin
* fatigue
* fatigue
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