49,259
edits
Difference between revisions of "Metanephric adenoma"
Jump to navigation
Jump to search
no edit summary
| (8 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Metanephric_adenoma_-_very_high_mag.jpg | | Image = Metanephric_adenoma_-_very_high_mag.jpg | ||
| Width = | | Width = | ||
| Caption = Metanephric adenoma. [[H&E stain]]. | | Caption = Metanephric adenoma. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = small uniform cells with fine chromatin, no apparent [[nucleolus]], and a relatively smooth nuclear membrane; variable architecture - may be sheets or | | Micro = small uniform cells with fine chromatin, no apparent [[nucleolus]], and a relatively smooth nuclear membrane; variable architecture - may be sheets, ductal or micropapillary, +/-[[psammoma bodies]] | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[Wilms tumour]], [[papillary renal cell carcinoma]] (type 1) | | LMDDx = [[Wilms tumour]], [[papillary renal cell carcinoma]] (type 1), [[renal mucinous tubular and spindle cell carcinoma]] | ||
| Stains = | | Stains = | ||
| IHC = WT-1 +ve, CD57 +ve, AMACR -ve, CD56 -ve | | IHC = WT-1 +ve, CD57 +ve, AMACR -ve, CD56 -ve | ||
| Line 40: | Line 40: | ||
*Afflicts adults and occasionally children. | *Afflicts adults and occasionally children. | ||
*May be associated with [[polycythemia]].<ref name=pmid21220212>{{Cite journal | last1 = Le Nué | first1 = R. | last2 = Marcellin | first2 = L. | last3 = Ripepi | first3 = M. | last4 = Henry | first4 = C. | last5 = Kretz | first5 = JM. | last6 = Geiss | first6 = S. | title = Conservative treatment of metanephric adenoma. A case report and review of the literature. | journal = J Pediatr Urol | volume = 7 | issue = 4 | pages = 399-403 | month = Aug | year = 2011 | doi = 10.1016/j.jpurol.2010.09.010 | PMID = 21220212 }}</ref> | *May be associated with [[polycythemia]].<ref name=pmid21220212>{{Cite journal | last1 = Le Nué | first1 = R. | last2 = Marcellin | first2 = L. | last3 = Ripepi | first3 = M. | last4 = Henry | first4 = C. | last5 = Kretz | first5 = JM. | last6 = Geiss | first6 = S. | title = Conservative treatment of metanephric adenoma. A case report and review of the literature. | journal = J Pediatr Urol | volume = 7 | issue = 4 | pages = 399-403 | month = Aug | year = 2011 | doi = 10.1016/j.jpurol.2010.09.010 | PMID = 21220212 }}</ref> | ||
==Gross== | |||
*Sharply circumscribed. | |||
*Not encapsulated.<ref name=pmid23551615>{{Cite journal | last1 = Mantoan Padilha | first1 = M. | last2 = Billis | first2 = A. | last3 = Allende | first3 = D. | last4 = Zhou | first4 = M. | last5 = Magi-Galluzzi | first5 = C. | title = Metanephric adenoma and solid variant of papillary renal cell carcinoma: common and distinctive features. | journal = Histopathology | volume = 62 | issue = 6 | pages = 941-53 | month = May | year = 2013 | doi = 10.1111/his.12106 | PMID = 23551615 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 47: | Line 51: | ||
**No apparent [[nucleolus]]. | **No apparent [[nucleolus]]. | ||
**A relatively smooth nuclear membrane. | **A relatively smooth nuclear membrane. | ||
*Variable architecture - may be sheets or | *Variable architecture - may be sheets, ductal or micropapillary. | ||
*+/-[[Psammoma bodies]]. | *+/-[[Psammoma bodies]]. | ||
| Line 56: | Line 60: | ||
**Mitoses (rare in ''metanephric adenoma''). | **Mitoses (rare in ''metanephric adenoma''). | ||
*[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | *[[Papillary renal cell carcinoma|Papillary RCC]].<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | ||
*[[Renal mucinous tubular and spindle cell carcinoma]]. | |||
*Other [[small round cell tumours]], e.g. [[small cell carcinoma]]. | *Other [[small round cell tumours]], e.g. [[small cell carcinoma]]. | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Metanephric_adenoma_high_mag.jpg | Metanephric adenoma (WC/Nephron) | Image:Metanephric_adenoma_high_mag.jpg | Metanephric adenoma. [[PAS stain]]. (WC/Nephron) | ||
Image:Metanephric_adenoma_high_mag_cropped.jpg | Metanephric adenoma - cropped (WC/Nephron) | Image:Metanephric_adenoma_high_mag_cropped.jpg | Metanephric adenoma - cropped. [[PAS stain]]. (WC/Nephron) | ||
</gallery> | </gallery> | ||
<gallery> | <gallery> | ||
| Line 83: | Line 88: | ||
==Sign out== | ==Sign out== | ||
<pre> | <pre> | ||
Left | Left Kidney, Total Nephrectomy: | ||
- Metanephric adenoma, see comment. | - Metanephric adenoma, see comment. | ||