Difference between revisions of "Pneumocytoma"
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===Micro=== | ===Micro=== | ||
The sections show lung with thickened alveolar walls containing bland appearing nuclei without conspicuous nucleoli. Necrosis is absent. | The sections show lung with thickened alveolar walls containing bland appearing cells with round/oval nuclei without conspicuous nucleoli. Necrosis is absent. | ||
==See also== | ==See also== | ||
Revision as of 20:39, 30 June 2017
| Pneumocytoma | |
|---|---|
| Diagnosis in short | |
 Pneumocytoma. H&E stain. (WC/Nephron) | |
|
| |
| Synonyms | sclerosing hemangioma, benign pneumocytoma |
|
| |
| LM | mixed cell population, variable architecture (papillary, sclerotic, solid, hemorrhagic), +/-granulomas |
| LM DDx | carcinoid tumour |
| IHC | TTF-1 +ve, Ki-67 +ve membranous pattern, PR +ve, CD56 -ve, CD34 -ve |
| Site | lung - see lung tumours |
|
| |
| Clinical history | typical patient - female 40s |
| Prevalence | rare <= 1% of lung tumours |
| Radiology | slow growth/no growth, typically peripheral location |
| Prognosis | benign, case reports of mets |
| Clin. DDx | other lung tumours |
| Treatment | usually excision, may be followed |
Pneumocytoma is a rare lung tumour that is typically benign. It is also known as sclerosing pneumocytoma.[1][2]
It was previously known as sclerosing hemangioma.[2]
General
- Derived from type 2 pneumocyte.[3]
- Progesterone-receptor positive stromal cells.[4]
- Rare - 0.2% to 1% of lung tumours.[5]
Management:
- Surgical excision preferred, may be followed.[5]
Epidemiology
- Female in 40s.[6]
- Considered benign; excision is curative.
- Rare case reports of metastases.[7][8]
Gross
- Peripheral, solitary.
- Well-circumscribed.
Microscopic
Features:[6]
- Mixed cell population.
- Variable architecture:
- Papillary.
- Sclerotic.
- Solid.
- Hemorrhagic.
- +/-Granulomas.
DDx:[9]
- Papillary adenoma.
- Neuroendocrine tumour (carcinoid).
Images
Pneumocytoma - low mag.
Pneumocytoma - intermed. mag.
Pneumocytoma - high mag.
Pneumocytoma - very high mag.
Pneumocytoma - low mag.
Pneumocytoma - intermed. mag.
IHC
Features:[10]
Negative stains:[10]
- SMA -ve.
- CEA -ve.
- CD34 -ve.
- S100 -ve.
- Chromogranin A -ve.
Others:[3]
- TTF-1 +ve.
- HNF-3 alpha +ve.
- HNF-3 beta +ve.
Images
Pneumocytoma - TTF-1 - intermed. mag.
Pneumocytoma - TTF-1 - high mag.
Pneumocytoma - Ki-67 (membranous) - intermed. mag.
Pneumocytoma - Ki-67 (membranous) - high mag.
Sign out
Lung, Left Lower Lobe, Core Biopsy:
- Sclerosing pneumocytoma (sclerosing hemangioma).
Comment:
The lesion stains as follows:
POSITIVE: Ki-67 (membranous pattern), TTF-1, PR.
NEGATIVE: CD56, p53, CD34.
Micro
The sections show lung with thickened alveolar walls containing bland appearing cells with round/oval nuclei without conspicuous nucleoli. Necrosis is absent.
See also
References
- ↑ Chan, KW.; Gibbs, AR.; Lo, WS.; Newman, GR. (Jun 1982). "Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).". Thorax 37 (6): 404-12. PMID 6291188.
- ↑ 2.0 2.1 Ruiz de la Cuesta, D.; Lafont Rufat, M.; Ruiz de la Cuesta Martín, E. (Jun 2013). "Pneumocytoma (formerly known as sclerosing hemangioma of the lung): a rare cause of chest pain.". Arch Bronconeumol 49 (6): 276-7. doi:10.1016/j.arbres.2012.10.004. PMID 23380035.
- ↑ 3.0 3.1 Yamazaki, K. (Jul 2004). "Type-II pneumocyte differentiation in pulmonary sclerosing hemangioma: ultrastructural differentiation and immunohistochemical distribution of lineage-specific transcription factors (TTF-1, HNF-3 alpha, and HNF-3 beta) and surfactant proteins.". Virchows Arch 445 (1): 45-53. doi:10.1007/s00428-004-1023-3. PMID 15138814.
- ↑ 4.0 4.1 Einsfelder, BM.; Müller, KM. (Sep 2005). "["Pneumocytoma" or "sclerosing hemangioma": histogenetic aspects of a rare tumor of the lung]". Pathologe 26 (5): 367-77. doi:10.1007/s00292-005-0751-8. PMID 15731902.
- ↑ 5.0 5.1 Salemis, NS.; Seretis, C.; Nakos, G.; Kantounakis, I.; Stoumpos, C.; Spiliopoulos, K. (Jan 2013). "Synchronous occurrence of breast cancer and pulmonary sclerosing hemangioma: management and review of the literature.". Breast Dis 34 (2): 61-5. doi:10.3233/BD-130352. PMID 23838116.
- ↑ 6.0 6.1 Keylock, JB.; Galvin, JR.; Franks, TJ. (May 2009). "Sclerosing hemangioma of the lung.". Arch Pathol Lab Med 133 (5): 820-5. PMID 19415961.
- ↑ Pokharel, S.; Dhillon, SS.; Ylagan, L.; George, S.; Yendamuri, S. (Oct 2016). "Sclerosing Pneumocytoma with Lymph Node Metastasis.". J Thorac Oncol 11 (10): 1802-4. doi:10.1016/j.jtho.2016.06.005. PMID 27346414.
- ↑ Tanaka, I.; Inoue, M.; Matsui, Y.; Oritsu, S.; Akiyama, O.; Takemura, T.; Fujiwara, M.; Kodama, T. et al. (Mar 1986). "A case of pneumocytoma (so-called sclerosing hemangioma) with lymph node metastasis.". Jpn J Clin Oncol 16 (1): 77-86. PMID 3009921.
- ↑ URL: http://www.med.muni.cz/biomedjournal/pdf/2004/01/37_42.pdf. Accessed on: 17 June 2010.
- ↑ 10.0 10.1 Rodriguez-Soto, J.; Colby, TV.; Rouse, RV. (Mar 2000). "A critical examination of the immunophenotype of pulmonary sclerosing hemangioma.". Am J Surg Pathol 24 (3): 442-50. PMID 10716159.
- ↑ Kim, BH.; Bae, YS.; Kim, SH.; Jeong, HJ.; Hong, SW.; Yoon, SO. (Feb 2013). "Usefulness of Ki-67 (MIB-1) immunostaining in the diagnosis of pulmonary sclerosing hemangiomas.". APMIS 121 (2): 105-10. doi:10.1111/j.1600-0463.2012.02945.x. PMID 23030396.