Difference between revisions of "Clear cell carcinoma"

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'''Clear cell carcinoma''', also '''clear cell adenocarcinoma''', is an aggressive uncommon malignancy seen in the [[gynecologic pathology|gynecologic tract]] and [[skin]].
[[Image:Clear cell renal cell carcinoma - 2 -- very high mag.jpg|thumb|right|[[Clear cell renal cell carcinoma]], a common carcinoma with clear cells. [[H&E stain]].]]
'''Clear cell carcinoma''', also '''clear cell adenocarcinoma''', is an aggressive uncommon [[malignancy]] seen in the [[gynecologic pathology|gynecologic tract]], [[skin]] and elsewhere.


A broader [[differential diagnosis]] for clear cell tumours is found in the ''[[clear cell tumours]]'' article.


==Ovary==
==Gynecologic pathology==
===Ovary===
:See ''[[Clear cell carcinoma of the ovary]]''.
:See ''[[Clear cell carcinoma of the ovary]]''.


==Cervix==
===Cervix===
:See ''[[Clear cell carcinoma of the uterine cervix]]''.
:See ''[[Clear cell carcinoma of the uterine cervix]]''.


==Vagina==
===Vagina===
:See ''[[Clear cell carcinoma of the vagina]]''.
:See ''[[Clear cell carcinoma of the vagina]]''.


==Skin==
==Skin==
:{{fact}}
*[[Basal cell carcinoma|Clear cell basal cell carcinoma]].<ref>{{Cite journal  | last1 = Sarma | first1 = DP. | last2 = Olson | first2 = D. | last3 = Olivella | first3 = J. | last4 = Harbert | first4 = T. | last5 = Wang | first5 = B. | last6 = Ortman | first6 = S. | title = Clear cell Basal cell carcinoma. | journal = Patholog Res Int | volume = 2011 | issue =  | pages = 386921 | month =  | year = 2011 | doi = 10.4061/2011/386921 | PMID = 21559201 }}</ref>
*Others.


==Clear cell variant of hepatocellular carcinoma==
==Gastrointestinal pathology==
===Clear cell variant of hepatocellular carcinoma===
{{Main|Hepatocellular carcinoma}}
{{Main|Hepatocellular carcinoma}}
Morphologically, it may be similar to clear cell [[renal cell carcinoma]].<ref name=pmid10955454>{{Cite journal  | last1 = Murakata | first1 = LA. | last2 = Ishak | first2 = KG. | last3 = Nzeako | first3 = UC. | title = Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. | journal = Mod Pathol | volume = 13 | issue = 8 | pages = 874-81 | month = Aug | year = 2000 | doi = 10.1038/modpathol.3880156 | PMID = 10955454 }}
Morphologically, it may be similar to clear cell [[renal cell carcinoma]].<ref name=pmid10955454>{{Cite journal  | last1 = Murakata | first1 = LA. | last2 = Ishak | first2 = KG. | last3 = Nzeako | first3 = UC. | title = Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma. | journal = Mod Pathol | volume = 13 | issue = 8 | pages = 874-81 | month = Aug | year = 2000 | doi = 10.1038/modpathol.3880156 | PMID = 10955454 }}
</ref>
</ref>


==Renal cell carcinoma==
==Genitourinary pathology==
===Urinary bladder===
:See ''[[Clear cell carcinoma of the urinary bladder]]''.
 
===Urethra===
:See ''[[Clear cell adenocarcinoma of the urethra]]''.
 
===Renal cell carcinoma===
These aren't always grouped with ''clear cell carcinoma''... but they have ''clear cell'' in the name:
These aren't always grouped with ''clear cell carcinoma''... but they have ''clear cell'' in the name:
*[[Clear cell renal cell carcinoma]].
*[[Clear cell renal cell carcinoma]].
*[[Clear cell papillary renal cell carcinoma]].
*[[Clear cell papillary renal cell carcinoma]].
Among others, clear cells may be seen in:
*[[Xp11.2 translocation carcinoma]].


==Head and neck pathology==
==Head and neck pathology==
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{{Main|Salivary gland}}
{{Main|Salivary gland}}
*Rare.
*Rare.
*Some consider it a variant of ''[[epithelial-myoepithelial carcinoma]]''.<ref name=pmid12033955>{{Cite journal  | last1 = Wang | first1 = B. | last2 = Brandwein | first2 = M. | last3 = Gordon | first3 = R. | last4 = Robinson | first4 = R. | last5 = Urken | first5 = M. | last6 = Zarbo | first6 = RJ. | title = Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. | journal = Arch Pathol Lab Med | volume = 126 | issue = 6 | pages = 676-85 | month = Jun | year = 2002 | doi = 10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2 | PMID = 12033955 }}</ref>
*Some consider clear cell carcinoma of the salivary gland a variant of ''[[epithelial-myoepithelial carcinoma]]''.<ref name=pmid12033955>{{Cite journal  | last1 = Wang | first1 = B. | last2 = Brandwein | first2 = M. | last3 = Gordon | first3 = R. | last4 = Robinson | first4 = R. | last5 = Urken | first5 = M. | last6 = Zarbo | first6 = RJ. | title = Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma. | journal = Arch Pathol Lab Med | volume = 126 | issue = 6 | pages = 676-85 | month = Jun | year = 2002 | doi = 10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2 | PMID = 12033955 }}</ref>


==See also==
==See also==

Latest revision as of 17:19, 9 January 2017

Clear cell renal cell carcinoma, a common carcinoma with clear cells. H&E stain.

Clear cell carcinoma, also clear cell adenocarcinoma, is an aggressive uncommon malignancy seen in the gynecologic tract, skin and elsewhere.

A broader differential diagnosis for clear cell tumours is found in the clear cell tumours article.

Gynecologic pathology

Ovary

See Clear cell carcinoma of the ovary.

Cervix

See Clear cell carcinoma of the uterine cervix.

Vagina

See Clear cell carcinoma of the vagina.

Skin

Gastrointestinal pathology

Clear cell variant of hepatocellular carcinoma

Morphologically, it may be similar to clear cell renal cell carcinoma.[2]

Genitourinary pathology

Urinary bladder

See Clear cell carcinoma of the urinary bladder.

Urethra

See Clear cell adenocarcinoma of the urethra.

Renal cell carcinoma

These aren't always grouped with clear cell carcinoma... but they have clear cell in the name:

Among others, clear cells may be seen in:

Head and neck pathology

Salivary gland

See also

References

  1. Sarma, DP.; Olson, D.; Olivella, J.; Harbert, T.; Wang, B.; Ortman, S. (2011). "Clear cell Basal cell carcinoma.". Patholog Res Int 2011: 386921. doi:10.4061/2011/386921. PMID 21559201.
  2. Murakata, LA.; Ishak, KG.; Nzeako, UC. (Aug 2000). "Clear cell carcinoma of the liver: a comparative immunohistochemical study with renal clear cell carcinoma.". Mod Pathol 13 (8): 874-81. doi:10.1038/modpathol.3880156. PMID 10955454.
  3. Wang, B.; Brandwein, M.; Gordon, R.; Robinson, R.; Urken, M.; Zarbo, RJ. (Jun 2002). "Primary salivary clear cell tumors--a diagnostic approach: a clinicopathologic and immunohistochemical study of 20 patients with clear cell carcinoma, clear cell myoepithelial carcinoma, and epithelial-myoepithelial carcinoma.". Arch Pathol Lab Med 126 (6): 676-85. doi:10.1043/0003-9985(2002)1260676:PSCCTA2.0.CO;2. PMID 12033955.