Difference between revisions of "Testicular metastasis"
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| Caption = Testis with metastatic prostate carcinoma. [[H&E stain]]. (WC) | | Caption = Testis with metastatic prostate carcinoma. [[H&E stain]]. (WC) | ||
| Synonyms = testicle with metastatic disease | | Synonyms = testicle with metastatic disease | ||
| Micro = atypical cells between seminiferous tubules, negative for [[ | | Micro = atypical cells between seminiferous tubules, negative for [[GCNIS]], +/-lymphovascular invasion | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = | | LMDDx = | ||
| Stains = | | Stains = | ||
| IHC = IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, SALL4 -ve) | | IHC = IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, [[SALL4]] -ve) | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 43: | Line 43: | ||
*[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | *[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | ||
*Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | *Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | ||
Most common in order:<ref name=pmid26066034/> | |||
*Prostate, lung, melanoma, kidney, GI tract. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Lack of [[ | *Lack of [[germ cell neoplasia in situ]] (GCNIS). | ||
*Atypical cells infiltrating between benign-appearing seminiferous tubules. | *Atypical cells infiltrating between benign-appearing seminiferous tubules. | ||
*+/-[[Lymphovascular invasion]]. | *+/-[[Lymphovascular invasion]]. | ||
Latest revision as of 14:44, 14 December 2016
| Testicular metastasis | |
|---|---|
| Diagnosis in short | |
 Testis with metastatic prostate carcinoma. H&E stain. (WC) | |
|
| |
| Synonyms | testicle with metastatic disease |
|
| |
| LM | atypical cells between seminiferous tubules, negative for GCNIS, +/-lymphovascular invasion |
| IHC | IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, SALL4 -ve) |
| Site | testis |
|
| |
| Clinical history | +/-history of malignancy |
| Signs | testicular mass |
| Prevalence | rare - esp. as first presentation |
| Prognosis | poor |
| Clin. DDx | primary testicular tumour |
Testicular metastasis is a the discontiguous spread of a malignant tumour to the testis.
General
- Rare as first presentation - case report worthy.[1][2]
- May be the first manifestation of an abdominal malignancy.[2]
Reports:
- Stomach (gastric carcinoma).[1]
- Pancreas.[2]
- Kidney (renal cell carcinoma).[3]
- Prostate.[4]
- Lung (squamous cell carcinoma of the lung).[5]
Most common in order:[2]
- Prostate, lung, melanoma, kidney, GI tract.
Microscopic
Features:
- Lack of germ cell neoplasia in situ (GCNIS).
- Atypical cells infiltrating between benign-appearing seminiferous tubules.
- +/-Lymphovascular invasion.
DDx:
- Germ cell tumours - esp. embryonal carcinoma.
- Malignant sex cord stromal tumour.
- Lymphoma.
Images
Testis with PCa - very low mag.
Testis with PCa - low mag.
Testis with PCa - intermed. mag.
Testis with PCa - intermed. mag.
Testis with PCa - high mag.
Testis with PCa - low mag.
Testis with PCa - intermed. mag.
Testis with PCa - high mag.
www
See also
References
- ↑ 1.0 1.1 Li, B.; Cai, H.; Kang, ZC.; Wu, H.; Hou, JG.; Ma, LY. (Jun 2015). "Testicular metastasis from gastric carcinoma: A case report.". World J Gastroenterol 21 (21): 6764-8. doi:10.3748/wjg.v21.i21.6764. PMID 26074716.
- ↑ 2.0 2.1 2.2 2.3 Cormio, L.; Sanguedolce, F.; Massenio, P.; Di Fino, G.; Bruno, M.; Carrieri, G. (2015). "Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report.". J Med Case Rep 9: 139. doi:10.1186/s13256-015-0626-4. PMID 26066034.
- ↑ Fragkoulis, C.; Pappas, A.; Goumas, G.; Gkialas, I.; Ntoumas, K.. "Renal cell carcinoma with metastasis to the testis.". J BUON 20 (2): 663. PMID 26011366.
- ↑ Shinn, BJ.; Greenwald, DW.; Ahmad, N. (2015). "Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma.". BMJ Case Rep 2015. doi:10.1136/bcr-2015-209914. PMID 25994435.
- ↑ 5.0 5.1 Buck, DA.; Byrd, RH.; Holmes, CL.; Pollock, T.. "Testicular metastasis in a case of squamous cell carcinoma of the lung.". Case Rep Oncol 8 (1): 133-7. doi:10.1159/000380814. PMID 25873879.