Difference between revisions of "Testicular metastasis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Testis with prostate carcinoma -- low mag.jpg | |||
| Width = | |||
| Caption = Testis with metastatic prostate carcinoma. [[H&E stain]]. (WC) | |||
| Synonyms = testicle with metastatic disease | |||
| Micro = atypical cells between seminiferous tubules, negative for [[GCNIS]], +/-lymphovascular invasion | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, [[SALL4]] -ve) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-history of malignancy | |||
| Signs = testicular mass | |||
| Symptoms = | |||
| Prevalence = rare - esp. as first presentation | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = poor | |||
| Other = | |||
| ClinDDx = primary testicular tumour | |||
| Tx = | |||
}} | |||
'''Testicular metastasis''' is a the discontiguous spread of a [[cancer|malignant tumour]] to the [[testis]]. | '''Testicular metastasis''' is a the discontiguous spread of a [[cancer|malignant tumour]] to the [[testis]]. | ||
==General== | ==General== | ||
*Rare - case report worthy.<ref name=pmid26074716>{{Cite journal | last1 = Li | first1 = B. | last2 = Cai | first2 = H. | last3 = Kang | first3 = ZC. | last4 = Wu | first4 = H. | last5 = Hou | first5 = JG. | last6 = Ma | first6 = LY. | title = Testicular metastasis from gastric carcinoma: A case report. | journal = World J Gastroenterol | volume = 21 | issue = 21 | pages = 6764-8 | month = Jun | year = 2015 | doi = 10.3748/wjg.v21.i21.6764 | PMID = 26074716 }}</ref><reF name=pmid26066034>{{Cite journal | last1 = Cormio | first1 = L. | last2 = Sanguedolce | first2 = F. | last3 = Massenio | first3 = P. | last4 = Di Fino | first4 = G. | last5 = Bruno | first5 = M. | last6 = Carrieri | first6 = G. | title = Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report. | journal = J Med Case Rep | volume = 9 | issue = | pages = 139 | month = | year = 2015 | doi = 10.1186/s13256-015-0626-4 | PMID = 26066034 }}</ref> | *Rare as first presentation - case report worthy.<ref name=pmid26074716>{{Cite journal | last1 = Li | first1 = B. | last2 = Cai | first2 = H. | last3 = Kang | first3 = ZC. | last4 = Wu | first4 = H. | last5 = Hou | first5 = JG. | last6 = Ma | first6 = LY. | title = Testicular metastasis from gastric carcinoma: A case report. | journal = World J Gastroenterol | volume = 21 | issue = 21 | pages = 6764-8 | month = Jun | year = 2015 | doi = 10.3748/wjg.v21.i21.6764 | PMID = 26074716 }}</ref><reF name=pmid26066034>{{Cite journal | last1 = Cormio | first1 = L. | last2 = Sanguedolce | first2 = F. | last3 = Massenio | first3 = P. | last4 = Di Fino | first4 = G. | last5 = Bruno | first5 = M. | last6 = Carrieri | first6 = G. | title = Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report. | journal = J Med Case Rep | volume = 9 | issue = | pages = 139 | month = | year = 2015 | doi = 10.1186/s13256-015-0626-4 | PMID = 26066034 }}</ref> | ||
*May be the first manifestation of an abdominal malignancy.<ref name=pmid26066034/> | *May be the first manifestation of an abdominal malignancy.<ref name=pmid26066034/> | ||
| Line 11: | Line 43: | ||
*[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | *[[Prostatic carcinoma|Prostate]].<ref name=pmid25994435>{{Cite journal | last1 = Shinn | first1 = BJ. | last2 = Greenwald | first2 = DW. | last3 = Ahmad | first3 = N. | title = Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma. | journal = BMJ Case Rep | volume = 2015 | issue = | pages = | month = | year = 2015 | doi = 10.1136/bcr-2015-209914 | PMID = 25994435 }}</ref> | ||
*Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | *Lung ([[squamous cell carcinoma of the lung]]).<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | ||
Most common in order:<ref name=pmid26066034/> | |||
*Prostate, lung, melanoma, kidney, GI tract. | |||
==Microscopic== | ==Microscopic== | ||
Features: | Features: | ||
*Lack of [[ | *Lack of [[germ cell neoplasia in situ]] (GCNIS). | ||
*Atypical cells | *Atypical cells infiltrating between benign-appearing seminiferous tubules. | ||
*+/-[[Lymphovascular invasion]]. | |||
DDx: | DDx: | ||
| Line 23: | Line 59: | ||
===Images=== | ===Images=== | ||
www | <gallery> | ||
Image: Testis with prostate carcinoma -- very low mag.jpg | Testis with PCa - very low mag. | |||
Image: Testis with prostate carcinoma -- low mag.jpg | Testis with PCa - low mag. | |||
Image: Testis with prostate carcinoma -- intermed mag.jpg | Testis with PCa - intermed. mag. | |||
Image: Testis with prostate carcinoma - alt -- intermed mag.jpg | Testis with PCa - intermed. mag. | |||
Image: Testis with prostate carcinoma -- high mag.jpg | Testis with PCa - high mag. | |||
Image: Testis with prostate carcinoma - 2 -- low mag.jpg | Testis with PCa - low mag. | |||
Image: Testis with prostate carcinoma - 2 -- intermed mag.jpg | Testis with PCa - intermed. mag. | |||
Image: Testis with prostate carcinoma - 2 -- high mag.jpg | Testis with PCa - high mag. | |||
</gallery> | |||
====www==== | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376918/figure/F1/ Lung squamous carcinoma in the testis (nih.gov)].<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376918/figure/F1/ Lung squamous carcinoma in the testis (nih.gov)].<ref name=pmid25873879>{{Cite journal | last1 = Buck | first1 = DA. | last2 = Byrd | first2 = RH. | last3 = Holmes | first3 = CL. | last4 = Pollock | first4 = T. | title = Testicular metastasis in a case of squamous cell carcinoma of the lung. | journal = Case Rep Oncol | volume = 8 | issue = 1 | pages = 133-7 | month = | year = | doi = 10.1159/000380814 | PMID = 25873879 }}</ref> | ||
| Line 29: | Line 76: | ||
*[[Testis]]. | *[[Testis]]. | ||
*[[Metastasis]]. | *[[Metastasis]]. | ||
*[[Ovarian metastasis]]. | |||
==References== | ==References== | ||
Latest revision as of 14:44, 14 December 2016
| Testicular metastasis | |
|---|---|
| Diagnosis in short | |
 Testis with metastatic prostate carcinoma. H&E stain. (WC) | |
|
| |
| Synonyms | testicle with metastatic disease |
|
| |
| LM | atypical cells between seminiferous tubules, negative for GCNIS, +/-lymphovascular invasion |
| IHC | IHC dependent on primary site (usually OCT4 -ve, AFP -ve, beta-hCG -ve, SALL4 -ve) |
| Site | testis |
|
| |
| Clinical history | +/-history of malignancy |
| Signs | testicular mass |
| Prevalence | rare - esp. as first presentation |
| Prognosis | poor |
| Clin. DDx | primary testicular tumour |
Testicular metastasis is a the discontiguous spread of a malignant tumour to the testis.
General
- Rare as first presentation - case report worthy.[1][2]
- May be the first manifestation of an abdominal malignancy.[2]
Reports:
- Stomach (gastric carcinoma).[1]
- Pancreas.[2]
- Kidney (renal cell carcinoma).[3]
- Prostate.[4]
- Lung (squamous cell carcinoma of the lung).[5]
Most common in order:[2]
- Prostate, lung, melanoma, kidney, GI tract.
Microscopic
Features:
- Lack of germ cell neoplasia in situ (GCNIS).
- Atypical cells infiltrating between benign-appearing seminiferous tubules.
- +/-Lymphovascular invasion.
DDx:
- Germ cell tumours - esp. embryonal carcinoma.
- Malignant sex cord stromal tumour.
- Lymphoma.
Images
Testis with PCa - very low mag.
Testis with PCa - low mag.
Testis with PCa - intermed. mag.
Testis with PCa - intermed. mag.
Testis with PCa - high mag.
Testis with PCa - low mag.
Testis with PCa - intermed. mag.
Testis with PCa - high mag.
www
See also
References
- ↑ 1.0 1.1 Li, B.; Cai, H.; Kang, ZC.; Wu, H.; Hou, JG.; Ma, LY. (Jun 2015). "Testicular metastasis from gastric carcinoma: A case report.". World J Gastroenterol 21 (21): 6764-8. doi:10.3748/wjg.v21.i21.6764. PMID 26074716.
- ↑ 2.0 2.1 2.2 2.3 Cormio, L.; Sanguedolce, F.; Massenio, P.; Di Fino, G.; Bruno, M.; Carrieri, G. (2015). "Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report.". J Med Case Rep 9: 139. doi:10.1186/s13256-015-0626-4. PMID 26066034.
- ↑ Fragkoulis, C.; Pappas, A.; Goumas, G.; Gkialas, I.; Ntoumas, K.. "Renal cell carcinoma with metastasis to the testis.". J BUON 20 (2): 663. PMID 26011366.
- ↑ Shinn, BJ.; Greenwald, DW.; Ahmad, N. (2015). "Unilateral testicular metastasis of low PSA level prostatic adenocarcinoma.". BMJ Case Rep 2015. doi:10.1136/bcr-2015-209914. PMID 25994435.
- ↑ 5.0 5.1 Buck, DA.; Byrd, RH.; Holmes, CL.; Pollock, T.. "Testicular metastasis in a case of squamous cell carcinoma of the lung.". Case Rep Oncol 8 (1): 133-7. doi:10.1159/000380814. PMID 25873879.