Difference between revisions of "Medullary breast carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
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| Synonyms = | |||
| Micro = all required: (1) lesion has well-circumscribed border, (2) syncytial growth pattern, (3) lymphocytic infiltrate, (4) high nuclear grade (as per Nottingham grading system), (5) no tubule formation | |||
| Subtypes = | |||
| LMDDx = [[Invasive ductal carcinoma of the breast|Invasive ductal carcinoma]] with medullary features | |||
| Stains = | |||
| IHC = ER -ve, PR -ve, HER2 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = [[breast grossing]] | |||
| Staging = [[breast cancer staging]] | |||
| Site = [[breast]] - see ''[[invasive breast cancer]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = better than NST | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]]. | '''Medullary breast carcinoma''' is an uncommon form of [[invasive breast carcinoma]]. | ||
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Epidemiology: | Epidemiology: | ||
*Thought to have a better prognosis that no special type (NST). | *Thought to have a better prognosis that no special type (NST). | ||
*May be associated with a BRCA1 mutation. | *May be associated with a [[BRCA1]] mutation. | ||
==Gross== | ==Gross== | ||
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#High nuclear grade (as per Nottingham grading system). | #High nuclear grade (as per Nottingham grading system). | ||
#No tubule formation. | #No tubule formation. | ||
DDx: | |||
*[[Invasive ductal carcinoma of the breast|Invasive ductal carcinoma]] with medullary features. | |||
==Images== | |||
<gallery> | |||
Image:Breast MedullaryCarcinoma (2) PA.JPG|Breast - Medullary Carcinoma - low power (SKB) | |||
Image:Breast MedullaryCarcinoma TripleNegative LP PA.JPG|Breast - Medullary Carcinoma - medium power (SKB) | |||
Image:Breast MedullaryCarcinoma TripleNegative HP PA.JPG|Breast - Medullary Carcinoma - high power (SKB) | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Latest revision as of 11:36, 8 September 2016
| Medullary breast carcinoma | |
|---|---|
| Diagnosis in short | |
|
| |
| LM | all required: (1) lesion has well-circumscribed border, (2) syncytial growth pattern, (3) lymphocytic infiltrate, (4) high nuclear grade (as per Nottingham grading system), (5) no tubule formation |
| LM DDx | Invasive ductal carcinoma with medullary features |
| IHC | ER -ve, PR -ve, HER2 -ve |
| Grossing notes | breast grossing |
| Staging | breast cancer staging |
| Site | breast - see invasive breast cancer |
|
| |
| Prevalence | uncommon |
| Prognosis | better than NST |
Medullary breast carcinoma is an uncommon form of invasive breast carcinoma.
It is also known as medullary carcinoma of the breast.
General
- Uncommon breast cancer subtype.
- Some pathologists very rarely make the diagnosis.[citation needed]
Epidemiology:
- Thought to have a better prognosis that no special type (NST).
- May be associated with a BRCA1 mutation.
Gross
- Well-circumscribed border.[1]
Aside - malignant well-circumscribed breast masses - radiologic DDx:[1]
- Medullary breast carcinoma.
- Mucinous breast carcinoma.
- Malignant phyllodes tumour.
- Invasive papillary carcinoma of the breast.
Microscopic
Features:
- Lesion has well-circumscribed border.
- Syncytial growth pattern = clumps of cells with poorly defined cell borders.
- Lymphocytic infiltrate.
- High nuclear grade (as per Nottingham grading system).
- No tubule formation.
DDx:
- Invasive ductal carcinoma with medullary features.
Images
Breast - Medullary Carcinoma - low power (SKB)
Breast - Medullary Carcinoma - medium power (SKB)
Breast - Medullary Carcinoma - high power (SKB)
_PA.JPG)
IHC
Features - typical:[2]
- ER -ve.
- PR -ve.
- HER2 -ve.
See also
References
- ↑ 1.0 1.1 Yoo, JL.; Woo, OH.; Kim, YK.; Cho, KR.; Yong, HS.; Seo, BK.; Kim, A.; Kang, EY. (Oct 2010). "Can MR Imaging contribute in characterizing well-circumscribed breast carcinomas?". Radiographics 30 (6): 1689-702. doi:10.1148/rg.306105511. PMID 21071383.
- ↑ Matkovic, B.; Juretic, A.; Separovic, V.; Novosel, I.; Separovic, R.; Gamulin, M.; Kruslin, B.. "Immunohistochemical analysis of ER, PR, HER-2, CK 5/6, p63 and EGFR antigen expression in medullary breast cancer.". Tumori 94 (6): 838-44. PMID 19267102.