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| *[http://path.upmc.edu/cases/case260/micro.html Microscopic polyangiitis - several images (upmc.edu)]. | | *[http://path.upmc.edu/cases/case260/micro.html Microscopic polyangiitis - several images (upmc.edu)]. |
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| ==Wegener granulomatosis== | | ==Granulomatosis with polyangiitis== |
| *Abbreviated ''WG''.
| | *[[AKA]] ''Wegener granulomatosis''. |
| *[[AKA]] ''granulomatosis with polyangiitis''. | | {{Main|Granulomatosis with polyangiitis}} |
| ===General===
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| *Autoimmune.
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| ====Clinical====
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| *Epistasis.
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| *Renal failure - present as ''nephritic syndrome''.
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| **Renal biopsy: crescentic glomerulonephritis ([[AKA]] [[rapidly progressive glomerulonephritis]]).
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| *[[Pulmonary hemorrhage]].
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| Serology:
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| *c-ANCA +ve.<ref name=Ref_TN2005_RH6>{{Ref TN2005|RH6}}</ref>
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| Notes:
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| *Pulmonary hemorrhage syndromes:<ref name=Ref_PBoD745>{{Ref PBoD|745}}</ref>
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| **[[Goodpasture syndrome]].
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| **Idiopathic pulmonary hemosiderosis.
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| **Vasculitis-assoc. hemorrhage (hypersensitivity angiitis, Wegener granulomatosis).
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| **[[Systemic lupus erythematosus]].
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| ===Microscopic===
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| Features:
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| *Small vessel vasculitis:
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| *#Inflammatory cells within the vessel wall.
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| *#*[[Granuloma]]s - typically poorly formed.<ref name=Ref_PBoD747>{{Ref PBoD|747}}</ref>
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| *#**Multinucleated giant cells - common. (???)
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| *#Vessel wall injury.
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| *#*[[Fibrinoid necrosis]].
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| Notes:
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| *In the lung, the [[granuloma]]s tend to be centrilobular, as the artery travels with the airway and is centrilobular.
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| **It may difficult to find small blood vessels in affected portions of lung.
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| ====Images====
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| <gallery>
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| Image:Wegener's granulomatosis - intermed mag.jpg | WG - intermed. mag. (WC)
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| Image:Wegener's granulomatosis - very high mag.jpg | WG - very high mag. (WC)
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| Image:Wegener's granulomatosis -b- intermed mag.jpg | WG - intermed. mag. (WC)
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| Image:Wegener's granulomatosis -b- high mag.jpg | WG - high mag. (WC)
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| Image:Wegener's granulomatosis -b- very high mag.jpg | WG - very high mag. (WC)
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| </gallery>
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| www:
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| *[http://www.flickr.com/photos/pulmonary_pathology/3734403695/ Wegener's granulomatosis (flickr.com)].
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| *[http://path.upmc.edu/cases/case269.html Wegener's granulomatosis - several crappy images (upmc.edu)].
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| *[http://path.upmc.edu/cases/case660.html Wegener's granulomatosis - more crappy images (upmc.edu)].
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| *[http://path.upmc.edu/cases/case675.html WG - more images (upmc.edu)].
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| ==Churg-Strauss syndrome== | | ==Churg-Strauss syndrome== |