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Difference between revisions of "Epithelioid sarcoma"
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'''Epithelioid sarcoma''' is a rare malignant [[soft tissue lesions|soft tissue lesion]]. | '''Epithelioid sarcoma''' is a rare malignant [[soft tissue lesions|soft tissue lesion]]. | ||
[[Sarcomas]] with an epithelioid morphology are covered in ''[[epithelioid sarcomas]]''. | |||
==General== | ==General== | ||
*Rare. | *Rare. | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Epithelioid sarcoma - low mag.jpg | ES - low mag. (WC/Nephron) | |||
Image:Epithelioid_sarcoma_-_intermed_mag.jpg | ES - intermed. mag. (WC/Nephron) | Image:Epithelioid_sarcoma_-_intermed_mag.jpg | ES - intermed. mag. (WC/Nephron) | ||
Image:Epithelioid_sarcoma_-_high_mag.jpg | ES - high mag. (WC/Nephron) | Image:Epithelioid_sarcoma_-_high_mag.jpg | ES - high mag. (WC/Nephron) | ||
Image:Epithelioid sarcoma - very high mag.jpg | ES - very high mag. (WC/Nephron) | |||
Image:Epithelioid sarcoma - cropped - very high mag.jpg | ES - cropped - very high mag. (WC/Nephron) | |||
Image:Epithelioid sarcoma -2- very high mag.jpg | ES - very high mag. (WC/Nephron) | |||
Image:Epithelioid sarcoma - smarcb1 - intermed mag.jpg | ES - SMARCB1/INI1 - intermed. mag. (WC/Nephron) | |||
Image:Epithelioid_sarcoma_-_smarcb1_-_high_mag.jpg | ES - SMARCB1/INI1 - high mag. (WC/Nephron) | Image:Epithelioid_sarcoma_-_smarcb1_-_high_mag.jpg | ES - SMARCB1/INI1 - high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
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==IHC== | ==IHC== | ||
Features:<ref name=pmid10452506>{{cite journal |author=Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF |title=Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis |journal=Hum. Pathol. |volume=30 |issue=8 |pages=934–42 |year=1999 |month=August |pmid=10452506 |doi= |url=}}</ref> | Features:<ref name=pmid10452506>{{cite journal |author=Miettinen M, Fanburg-Smith JC, Virolainen M, Shmookler BM, Fetsch JF |title=Epithelioid sarcoma: an immunohistochemical analysis of 112 classical and variant cases and a discussion of the differential diagnosis |journal=Hum. Pathol. |volume=30 |issue=8 |pages=934–42 |year=1999 |month=August |pmid=10452506 |doi= |url=}}</ref> | ||
*INI1 (SMARCB1<ref>{{OMIM|601607}}</ref>) -ve.<ref name=pmid19997734>{{cite journal |author=Mentzel T |title=[Epithelioid sarcoma: morphologic variants and differential diagnosis] |language=German |journal=Pathologe |volume=31 |issue=2 |pages=135–41 |year=2010 |month=March |pmid=19997734 |doi=10.1007/s00292-009-1250-0 |url=}}</ref> | *[[INI1]] (SMARCB1<ref>{{OMIM|601607}}</ref>) -ve.<ref name=pmid19997734>{{cite journal |author=Mentzel T |title=[Epithelioid sarcoma: morphologic variants and differential diagnosis] |language=German |journal=Pathologe |volume=31 |issue=2 |pages=135–41 |year=2010 |month=March |pmid=19997734 |doi=10.1007/s00292-009-1250-0 |url=}}</ref> | ||
*Vimentin +ve. | *[[Vimentin]] +ve. | ||
*Various keratins +ve. | *Various keratins +ve. | ||
**Keratin 8, Keratin 19 +ve. | **Keratin 8, Keratin 19 +ve. | ||
| Line 83: | Line 88: | ||
*S100 -ve (r/o melanoma). | *S100 -ve (r/o melanoma). | ||
*CK7 +ve / CK20 -ve.<ref name=pmid12680954>{{Cite journal | last1 = Humble | first1 = SD. | last2 = Prieto | first2 = VG. | last3 = Horenstein | first3 = MG. | title = Cytokeratin 7 and 20 expression in epithelioid sarcoma. | journal = J Cutan Pathol | volume = 30 | issue = 4 | pages = 242-6 | month = Apr | year = 2003 | doi = | PMID = 12680954 }}</ref> | *CK7 +ve / CK20 -ve.<ref name=pmid12680954>{{Cite journal | last1 = Humble | first1 = SD. | last2 = Prieto | first2 = VG. | last3 = Horenstein | first3 = MG. | title = Cytokeratin 7 and 20 expression in epithelioid sarcoma. | journal = J Cutan Pathol | volume = 30 | issue = 4 | pages = 242-6 | month = Apr | year = 2003 | doi = | PMID = 12680954 }}</ref> | ||
*CA-125 +ve.<ref name=pmid19756736/><ref name=pmid16740043>{{Cite journal | last1 = Lee | first1 = HI. | last2 = Kang | first2 = KH. | last3 = Cho | first3 = YM. | last4 = Lee | first4 = OJ. | last5 = Ro | first5 = JY. | title = Proximal-type epithelioid sarcoma with elevated serum CA 125: report of a case with CA 125 immunoreactivity. | journal = Arch Pathol Lab Med | volume = 130 | issue = 6 | pages = 871-4 | month = Jun | year = 2006 | doi = 10.1043/1543-2165(2006)130[871:PESWES]2.0.CO;2 | PMID = 16740043 }}</ref> | *[[CA-125]] +ve.<ref name=pmid19756736/><ref name=pmid16740043>{{Cite journal | last1 = Lee | first1 = HI. | last2 = Kang | first2 = KH. | last3 = Cho | first3 = YM. | last4 = Lee | first4 = OJ. | last5 = Ro | first5 = JY. | title = Proximal-type epithelioid sarcoma with elevated serum CA 125: report of a case with CA 125 immunoreactivity. | journal = Arch Pathol Lab Med | volume = 130 | issue = 6 | pages = 871-4 | month = Jun | year = 2006 | doi = 10.1043/1543-2165(2006)130[871:PESWES]2.0.CO;2 | PMID = 16740043 }}</ref> | ||
==See also== | ==See also== | ||