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[[Image:Seminoma with necrosis -- high mag.jpg|thumb|right|Necrosis (left of image) in a [[seminoma]] (right of image). [[H&E stain]].]] | |||
'''Necrosis''' is a type of cell death that is characterized by inflammation. | '''Necrosis''' is a type of cell death that is characterized by inflammation. | ||
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===Other classic types=== | ===Other classic types=== | ||
*Gangrenous: coagulative necrosis in ischemic limb. | *Gangrenous: coagulative necrosis in ischemic limb. | ||
*Caseous: | *Caseous: cheesy material; [[tuberculosis]]. | ||
*Fat: adipose tissue, e.g. pancreatitis. | *Fat: adipose tissue, e.g. pancreatitis. | ||
*Fibrinoid: immune complex mediated; bright-pink in vessel walls. | *Fibrinoid: immune complex mediated; bright-pink in vessel walls. | ||
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*[[Contraction band necrosis]]. | *[[Contraction band necrosis]]. | ||
*Dirty necrosis. | *Dirty necrosis. | ||
*Radiation necrosis. | |||
==Gross== | ==Gross== | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Cat_scratch_disease_-_very_high_mag.jpg | Necrosis in cat scratch disease (WC/Nephron) | Image:Cat_scratch_disease_-_very_high_mag.jpg | Necrosis in [[cat scratch disease]]. (WC/Nephron) | ||
Image:Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg | Necrosis in histiocytic necrotizing lymphadenitis (WC/Nephron) | Image:Histiocytic_necrotizing_lymphadenitis_-_very_high_mag.jpg | Necrosis in [[histiocytic necrotizing lymphadenitis]]. (WC/Nephron) | ||
Image:Systemic_lupus_erythematosus_lymphadenopathy_-_high_mag.jpg | Necrosis in SLE lymphadenopathy (WC/Nephron) | Image:Systemic_lupus_erythematosus_lymphadenopathy_-_high_mag.jpg | Necrosis in [[SLE lymphadenopathy]]. (WC/Nephron) | ||
Image:Fat_necrosis_-_high_mag.jpg | Fat necrosis - high mag. (WC/Nephron) | Image:Fat_necrosis_-_high_mag.jpg | Fat necrosis - high mag. (WC/Nephron) | ||
Image:Necrotic_bone_and_inflammation_-_alt_--_intermed_mag.jpg | Necrotic [[bone]]. (WC/Nephron) | |||
File:Pathology Brain Radiation Necrosis 2.jpg | Radiation necrosis in the CNS. (WC/Tdvorak) | |||
</gallery> | </gallery> | ||
www: | www: | ||
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==Stains== | ==Stains== | ||
*[[Martius scarlet blue stain]] - fibroid necrosis = red. | *[[Martius scarlet blue stain]] - fibroid necrosis = red. | ||
==Sign out== | |||
<pre> | |||
LESION, ANTERIOR RECTUS WALL, SURGICAL BIOPSY: | |||
- EXTENSIVE FAT NECROSIS. | |||
- NO EVIDENCE OF MALIGNANCY. | |||
</pre> | |||
===Micro=== | |||
The sections show fibroadipose tissue with abundant foamy histiocytes and necrotic adipocytes. Scattered chronic inflammatory cells, including plasma cells eosinophils and lymphocytes, are present. Focally hemosiderin-laden macrophages are identified. Multi-nucleated giant cells are seen. No definite epithelium is identified. Some reactive fibroblasts are present. No significant nuclear atypia is identified. | |||
==See also== | ==See also== | ||