Difference between revisions of "Columnar cell change of the breast"
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(Created page with "'''Columnar cell change of the breast''', usually '''columnar cell change''' (abbreviated '''CCC'''), is a benign finding in breast pathology. It is also known as '''blun...") |
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==General== | ==General== | ||
*Columnar cell change is associated with (benign) [[breast calcification|calcification]] - '''key point'''. | *Columnar cell change is associated with (benign) [[breast calcification|calcification]]<ref name=pmid19089736>{{Cite journal | last1 = Jara-Lazaro | first1 = AR. | last2 = Tse | first2 = GM. | last3 = Tan | first3 = PH. | title = Columnar cell lesions of the breast: an update and significance on core biopsy. | journal = Pathology | volume = 41 | issue = 1 | pages = 18-27 | month = Jan | year = 2009 | doi = 10.1080/00313020802563486 | PMID = 19089736 }}</ref> - '''key point'''. | ||
==Microscopic== | ==Microscopic== | ||
Revision as of 04:50, 1 July 2016
Columnar cell change of the breast, usually columnar cell change (abbreviated CCC), is a benign finding in breast pathology.
It is also known as blunt duct adenosis.
General
- Columnar cell change is associated with (benign) calcification[1] - key point.
Microscopic
Features:
- Secretory cells (line gland lumen) have columnar morphology.
- May have "apical snouts".
- Blebs or round balls eosinophilic material appear to be adjacent to the cell at their luminal surface.
- The snouts are attached to the cell-- appear as round ball only in the plane of section.
- Cytoplasm +/-eosinophilia.
- Often purple luminal calcifications
DDx:
- Flat epithelial atypia (>2 cell layers).[citation needed]
- If the columnar cells shows low to intermediate grade atypia the process is termed "flat epithelial atypia"
- If higher grade atyia is present the lesion is termed "flat DCIS" (clinging carcinoma)
Images
CCC - intermed. mag.
CCC - high mag.
CCC - very high mag.
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- Usually not reported.
See also
References
- ↑ Jara-Lazaro, AR.; Tse, GM.; Tan, PH. (Jan 2009). "Columnar cell lesions of the breast: an update and significance on core biopsy.". Pathology 41 (1): 18-27. doi:10.1080/00313020802563486. PMID 19089736.