Difference between revisions of "Necrobiotic xanthogranuloma"

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==General==
==General==
*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref>
*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref>
*Associated with monoclonal gammopathy in most cases.<ref name=pmid25566570>{{Cite journal  | last1 = Seastrom | first1 = S. | last2 = Bookout | first2 = A. | last3 = Hogan | first3 = DJ. | title = Necrobiotic xanthogranuloma without a monoclonal gammopathy. | journal = Cutis | volume = 94 | issue = 6 | pages = 293-6 | month = Dec | year = 2014 | doi =  | PMID = 25566570 }}</ref>


==Gross==
==Gross==

Revision as of 20:14, 17 June 2016

Necrobiotic xanthogranuloma, abbreviated NXG, is a rare granulomatous skin condition.

General

  • Usually elderly.[1]
  • Associated with monoclonal gammopathy in most cases.[2]

Gross

Features:

  • Periorbital - classic location.[3]

Microscopic

Features:[1]

  • "Necrobiotic granuloma":
    • Palisading granuloma with a core collagen-like material.
  • +/-Cholesterol clefts - common.
  • +/-Touton giant cells.
  • +/-Atypical foreign body-type giant cells +/- asteroid bodies.

DDx:

Image

See also

References

  1. 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 629. ISBN 978-0443066542.
  2. Seastrom, S.; Bookout, A.; Hogan, DJ. (Dec 2014). "Necrobiotic xanthogranuloma without a monoclonal gammopathy.". Cutis 94 (6): 293-6. PMID 25566570.
  3. Fernández-Herrera, J.; Pedraz, J. (Jun 2007). "Necrobiotic xanthogranuloma.". Semin Cutan Med Surg 26 (2): 108-13. doi:10.1016/j.sder.2007.02.008. PMID 17544963.