Difference between revisions of "Necrobiotic xanthogranuloma"
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'''Necrobiotic xanthogranuloma''', abbreviated '''NXG''', is a rare [[granuloma|granulomatous]] [[skin]] condition. | |||
==General== | |||
*Usually elderly.<ref name=Ref_Derm629>{{Ref Derm|629}}</ref> | |||
==Gross== | |||
Features: | |||
*Periorbital - classic location.<ref name=pmid17544963>{{Cite journal | last1 = Fernández-Herrera | first1 = J. | last2 = Pedraz | first2 = J. | title = Necrobiotic xanthogranuloma. | journal = Semin Cutan Med Surg | volume = 26 | issue = 2 | pages = 108-13 | month = Jun | year = 2007 | doi = 10.1016/j.sder.2007.02.008 | PMID = 17544963 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_Derm629>{{Ref Derm|629}}</ref> | |||
*"Necrobiotic granuloma": | |||
**Palisading granuloma with a core collagen-like material. | |||
*+/-Cholesterol clefts - common. | |||
*+/-[[Touton giant cell]]s. | |||
*+/-Atypical foreign body-type giant cells +/- asteroid bodies. | |||
DDx: | |||
*[[Granuloma annulare]]. | |||
*[[Necrobiosis lipoidica]] - has plasma cells. | |||
*Granuloma-forming infections - positive stains for microorganisms. | |||
===Image=== | |||
*[http://commons.wikimedia.org/wiki/File:Asteroid_bodies_high_mag_cropped.jpg Asteroid body (WC)]. | |||
==See also== | |||
*[[Inflammatory skin disorders]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 20:13, 17 June 2016
Necrobiotic xanthogranuloma, abbreviated NXG, is a rare granulomatous skin condition.
General
- Usually elderly.[1]
Gross
Features:
- Periorbital - classic location.[2]
Microscopic
Features:[1]
- "Necrobiotic granuloma":
- Palisading granuloma with a core collagen-like material.
- +/-Cholesterol clefts - common.
- +/-Touton giant cells.
- +/-Atypical foreign body-type giant cells +/- asteroid bodies.
DDx:
- Granuloma annulare.
- Necrobiosis lipoidica - has plasma cells.
- Granuloma-forming infections - positive stains for microorganisms.
Image
See also
References
- ↑ 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 629. ISBN 978-0443066542.
- ↑ Fernández-Herrera, J.; Pedraz, J. (Jun 2007). "Necrobiotic xanthogranuloma.". Semin Cutan Med Surg 26 (2): 108-13. doi:10.1016/j.sder.2007.02.008. PMID 17544963.