48,470
edits
Difference between revisions of "Low-grade squamous intraepithelial lesion"
Jump to navigation
Jump to search
Low-grade squamous intraepithelial lesion (view source)
Revision as of 14:29, 6 May 2016
, 14:29, 6 May 2016no edit summary
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = Low-grade squamous intraepithelial lesion -- high mag.jpg | | Image = Low-grade squamous intraepithelial lesion -- high mag.jpg | ||
| Width = | | Width = | ||
| Caption = LSIL. [[H&E stain]]. | | Caption = LSIL. [[H&E stain]]. | ||
| Line 33: | Line 32: | ||
'''Low-grade squamous intraepithelial lesion''', abbreviated '''LSIL''', is a pre-cancerous lesions of the [[uterine cervix]]. | '''Low-grade squamous intraepithelial lesion''', abbreviated '''LSIL''', is a pre-cancerous lesions of the [[uterine cervix]]. | ||
Increasingly, the term is being applied to other anatomical sites, e.g. [[vagina]]. | Increasingly, the term is being applied to other anatomical sites, e.g. [[vagina]], [[anal intraepithelial lesions|anus]]. | ||
It is in the larger category of '''[[Squamous intraepithelial lesion of the uterine cervix|squamous intraepithelial lesion]]''', abbreviated '''SIL'''. | It is in the larger category of '''[[Squamous intraepithelial lesion of the uterine cervix|squamous intraepithelial lesion]]''', abbreviated '''SIL'''. | ||
| Line 114: | Line 113: | ||
www: | www: | ||
*[http://www.flickr.com/photos/jian-hua_qiao_md/3987000055/ CIN 1 (flickr.com/Qiao)]. | *[http://www.flickr.com/photos/jian-hua_qiao_md/3987000055/ CIN 1 (flickr.com/Qiao)]. | ||
*[https://www.flickr.com/photos/jian-hua_qiao_md/3986999903/ CIN 1 (flickr.com/Qiao)]. | |||
*[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod6img1a.html CIN 1 (eurocytology.eu)]. | *[http://www.eurocytology.eu/static/eurocytology/eng/cervical/mod6img1a.html CIN 1 (eurocytology.eu)]. | ||
| Line 132: | Line 132: | ||
<pre> | <pre> | ||
UTERINE CERVIX, BIOPSY: | UTERINE CERVIX, BIOPSY: | ||
- | - FRAGMENTS OF SQUAMOUS EPITHELIUM SHOWING DYSPLASIA, SEE COMMENT. | ||
COMMENT: | COMMENT: | ||
| Line 139: | Line 139: | ||
to distinguish low-grade from high-grade in this specimen. That said, | to distinguish low-grade from high-grade in this specimen. That said, | ||
there is at least low grade-dysplasia. Follow-up is recommended with | there is at least low grade-dysplasia. Follow-up is recommended with | ||
re-biopsy if clinically indicated. | |||
</pre> | |||
===Biopsy - cannot grade=== | |||
<pre> | |||
UTERINE CERVIX, BIOPSY: | |||
- AT LEAST LOW-GRADE SQUAMOUS INTRAEPITHELIAL LESION (LSIL), SEE COMMENT. | |||
- BENIGN ENDOCERVICAL EPITHELIUM. | |||
COMMENT: | |||
A concerning area of dysplastic squamous epithelium is missing its surface cells. This | |||
precludes assessment for a high-grade lesion. Follow-up is recommended with | |||
re-biopsy if clinically indicated. | re-biopsy if clinically indicated. | ||
</pre> | </pre> | ||
| Line 182: | Line 194: | ||
The Ki-67 positive cells are confined to the lower aspect of the squamous epithelium. | The Ki-67 positive cells are confined to the lower aspect of the squamous epithelium. | ||
A p16 stain is negative. | A p16 stain is negative. | ||
</pre> | |||
<pre> | |||
COMMENT: | |||
A p16 immunostain is strong and diffuse in the lower aspect of squamous epithelium, | |||
and weak and patchy in the superficial portions; this is compatible with LSIL. | |||
</pre> | </pre> | ||
| Line 194: | Line 212: | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
==External links== | |||
*[http://www.medecine.ups-tlse.fr/dcem1/histologie/courtade/CINtec.pdf Interpretation altas for p16 staining (ups-tlse.fr)]. | |||
[[Category:Uterine cervix]] | [[Category:Uterine cervix]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||