Difference between revisions of "Radiation esophagitis"

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'''Radiation esophagitis''' is a relatively uncommon pathology of the [[esophagus]] seen in the context of radiation treatments for thoracic malignancies.
'''Radiation esophagitis''' is a relatively uncommon pathology of the [[esophagus]], typically seen in the context of radiation treatments for thoracic [[cancer|malignancies]].


==General==
==General==
*Uncommon ~1% of patients getting radiation.<ref name=pmid26030254>{{Cite journal  | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref>
*Uncommon ~1% of patients getting (thoracic) radiation.<ref name=pmid26030254>{{Cite journal  | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref>
 
==Gross/endoscopic==
Features:
*Erythema - nonspecific.<ref name=pmid26030254/>
 
==Microscopic==
Features:<ref name=pmid26030254/>
*Variable inflammation.
*Radiation-related [[nuclear atypia]] - endothelial cells and stromal cells.
 
DDx:
*[[Cytomegalovirus]].
 
==IHC==
*[[CMV]] -ve.


==Sign out==
==Sign out==
<pre>
<pre>
<pre>
Esophagus, 25 cm, Biopsy:
Esophagus, 25 cm, Biopsy:
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Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.
Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.
</pre>
</pre>
==See also==
*[[Radiation changes]].
==References==
{{Reflist|1}}


[[Category:Gastrointestinal pathology]]
[[Category:Gastrointestinal pathology]]
[[Category:Diagnosis]]
[[Category:Diagnosis]]

Latest revision as of 12:38, 15 April 2016

Radiation esophagitis is a relatively uncommon pathology of the esophagus, typically seen in the context of radiation treatments for thoracic malignancies.

General

  • Uncommon ~1% of patients getting (thoracic) radiation.[1]

Gross/endoscopic

Features:

  • Erythema - nonspecific.[1]

Microscopic

Features:[1]

  • Variable inflammation.
  • Radiation-related nuclear atypia - endothelial cells and stromal cells.

DDx:

IHC

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Esophagus, 25 cm, Biopsy:
- Acute esophagitis with edema, see comment.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.

Comment:
The history of radiation is noted. 

Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.

See also

References

  1. 1.0 1.1 1.2 Murro, D.; Jakate, S. (Jun 2015). "Radiation esophagitis.". Arch Pathol Lab Med 139 (6): 827-30. doi:10.5858/arpa.2014-0111-RS. PMID 26030254.