Difference between revisions of "Radiation esophagitis"

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==General==
==General==
*Uncommon ~1% of patients getting radiation.<ref name=pmid26030254>{{Cite journal  | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref>
*Uncommon ~1% of patients getting radiation.<ref name=pmid26030254>{{Cite journal  | last1 = Murro | first1 = D. | last2 = Jakate | first2 = S. | title = Radiation esophagitis. | journal = Arch Pathol Lab Med | volume = 139 | issue = 6 | pages = 827-30 | month = Jun | year = 2015 | doi = 10.5858/arpa.2014-0111-RS | PMID = 26030254 }}</ref>
==Microscopic==
Features:<ref name=pmid26030254/>
*Variable inflammation.
*Radiation-related [[nuclear atypia]] - endothelial cells and stromal cells.
DDx:
*[[Cytomegalovirus]].
==IHC==
*[[CMV]] -ve.


==Sign out==
==Sign out==

Revision as of 17:05, 14 April 2016

Radiation esophagitis is a relatively uncommon pathology of the esophagus seen in the context of radiation treatments for thoracic malignancies.

General

  • Uncommon ~1% of patients getting radiation.[1]

Microscopic

Features:[1]

  • Variable inflammation.
  • Radiation-related nuclear atypia - endothelial cells and stromal cells.

DDx:

IHC

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<pre>
Esophagus, 25 cm, Biopsy:
- Acute esophagitis with edema, see comment.
- NEGATIVE for dysplasia and NEGATIVE for malignancy.

Comment:
The history of radiation is noted. 

Stains are pending to exclude micro-organisms not appreciated on H&E staining; the results will be reported in an addendum.

See also

References

  1. 1.0 1.1 Murro, D.; Jakate, S. (Jun 2015). "Radiation esophagitis.". Arch Pathol Lab Med 139 (6): 827-30. doi:10.5858/arpa.2014-0111-RS. PMID 26030254.