Difference between revisions of "Biphenotypic sinonasal sarcoma"
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*Actin +ve. | *Actin +ve. | ||
*S-100 +ve (strong). | *S-100 +ve (strong). | ||
==Molecular== | |||
*PAX3-MAML3 fusion - t(2;4)(q35;q31.1).<ref name=pmid24859338>{{Cite journal | last1 = Wang | first1 = X. | last2 = Bledsoe | first2 = KL. | last3 = Graham | first3 = RP. | last4 = Asmann | first4 = YW. | last5 = Viswanatha | first5 = DS. | last6 = Lewis | first6 = JE. | last7 = Lewis | first7 = JT. | last8 = Chou | first8 = MM. | last9 = Yaszemski | first9 = MJ. | title = Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma. | journal = Nat Genet | volume = 46 | issue = 7 | pages = 666-8 | month = Jul | year = 2014 | doi = 10.1038/ng.2989 | PMID = 24859338 }}</ref> | |||
==See also== | ==See also== | ||
Revision as of 16:08, 13 March 2016
Biphenotypic sinonasal sarcoma is a rare bland appearing malignant tumour of the head and neck.
It is also known as low grade sinonasla sarcoma with neural and myogenic features, abbreviated LGSSNMF.
General
- Rare.
- Female predominant.
Microscopic
Features;
- Bland hypercellular stroma typically without many mitoses.
- Invaginating glandular epithelium.
DDx:
IHC
- Actin +ve.
- S-100 +ve (strong).
Molecular
- PAX3-MAML3 fusion - t(2;4)(q35;q31.1).[1]
See also
References
- ↑ Wang, X.; Bledsoe, KL.; Graham, RP.; Asmann, YW.; Viswanatha, DS.; Lewis, JE.; Lewis, JT.; Chou, MM. et al. (Jul 2014). "Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.". Nat Genet 46 (7): 666-8. doi:10.1038/ng.2989. PMID 24859338.