49,016
edits
Difference between revisions of "Clear cell carcinoma of the uterine cervix"
Jump to navigation
Jump to search
Clear cell carcinoma of the uterine cervix (view source)
Revision as of 06:45, 30 December 2015
, 06:45, 30 December 2015no edit summary
| (10 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Clear cell carcinoma - gynecologic tract -- very high mag.jpg | |||
| Width = | |||
| Caption = Clear cell carcinoma of the gynecologic tract with focal clear cells. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = cells with clear cytoplasm (may be focal), hobnail pattern), moderate-to-severe [[nuclear pleomorphism]], usu. tubular and/or cystic morphology (may be (simple) papillary and/or solid) | |||
| Subtypes = | |||
| LMDDx = [[clear cell carcinoma of the vagina]], [[clear cell carcinoma of the endometrium]], [[serous carcinoma of the endometrium]], [[serous carcinoma]] of the uterine cervix, [[mesonephric adenocarcinoma]], other [[clear cell tumours]] | |||
| Stains = PAS +ve, PASD -ve | |||
| IHC = CK7 +ve, ER -ve, PR -ve, CA-125 +ve, CEA -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Staging = | |||
| Site = [[uterine cervix]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-diethylstilbestrol (DES) exposure, "young" (median age ~38 years old) | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | '''Clear cell carcinoma of the uterine cervix''', also '''cervical clear cell carcinoma''', is a rare malignancy of the [[uterine cervix]] that classically is associated with diethylstilbestrol (DES) exposure. It typically occurs in younger women. | ||
| Line 12: | Line 44: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=pmid22885379/> | Features:<ref name=pmid22885379/> | ||
* | *Cells with clear cytoplasm - '''key feature'''. | ||
**May be focal/absent! | |||
**Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | **Cells have large free/luminal surface area (hobnailing pattern) and small non-free surface. | ||
*Moderate-to-severe [[nuclear pleomorphism]]. | |||
*Tubular and/or cystic morphology. | |||
**May be (simple) papillary and/or solid. | |||
*Adenosis - typically adjacent. | *Adenosis - typically adjacent. | ||
| Line 24: | Line 55: | ||
*[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | *[[Clear cell carcinoma of the endometrium]] - diagnosis based on clinico-radiologic correlation (IHC & histology not useful).<ref name=pmid22885379>{{Cite journal | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref> | ||
*[[Serous carcinoma of the endometrium]]. | *[[Serous carcinoma of the endometrium]]. | ||
*[[Serous carcinoma of the uterine cervix]]. | *[[Serous carcinoma]] of the uterine cervix. | ||
*[[Mesonephric adenocarcinoma]]. | |||
===Images=== | ===Images=== | ||
www: | www: | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891640/figure/f1-ott-7-111/ Cervical CCC (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891640/figure/f1-ott-7-111/ Cervical CCC (nih.gov)].<ref name=pmid24470762/> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862311/figure/f0010/ Cervical CCC (nih.gov)]. | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862311/figure/f0010/ Cervical CCC (nih.gov)]. | ||
==IHC== | ==IHC== | ||
* | Features:<ref>{{Ref_GP|120}}</ref> | ||
*CK7 +ve. | |||
*ER -ve. | |||
*PR -ve. | |||
Others - one case only:<ref>{{Cite journal | last1 = Terada | first1 = T. | title = Clear cell adenocarcinoma of the uterine cervix in a young pregnant woman: a case report with immunohistochemical study. | journal = Med Oncol | volume = 28 | issue = 1 | pages = 290-3 | month = Mar | year = 2011 | doi = 10.1007/s12032-009-9410-x | PMID = 20054717 }}</ref> | |||
*CA-125 +ve. | |||
*p53 +ve. | |||
*CEA -ve. | |||
*CK34betaE12 -ve. | |||
==See also== | ==See also== | ||