Difference between revisions of "Glioblastoma"

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**Endothelial proliferation ([[AKA]] microvascular proliferation).
**Endothelial proliferation ([[AKA]] microvascular proliferation).
**+/-"Pseudopalisading necrosis" - tumour cells lined-up like a picket fence around necrotic areas.
**+/-"Pseudopalisading necrosis" - tumour cells lined-up like a picket fence around necrotic areas.
Glioblastoma variants:
*Giant cell glioblastoma (ICD-O: 9441/3)
*[[Gliosarcoma]] (ICD-O: 9442/3)
*Future variant (in 2016?)
**Epitheloid glioblastoma (50% BRAF V600E mutations) <ref>te journal  | last1 = Kleinschmidt-DeMasters | first1 = BK. | last2 = Aisner | first2 = DL. | last3 = Birks | first3 = DK. | last4 = Foreman | first4 = NK. | title = Epithelioid GBMs show a high percentage of BRAF V600E mutation. | journal = Am J Surg Pathol | volume = 37 | issue = 5 | pages = 685-98 | month = May | year = 2013 | doi = 10.1097/PAS.0b013e31827f9c5e | PMID = 23552385 }}</ref>
Morphological patterns in Glioblastoma:
* Lipidized (foamy)cells <ref>{{Cite journal  | last1 = Kepes | first1 = JJ. | last2 = Rubinstein | first2 = LJ. | title = Malignant gliomas with heavily lipidized (foamy) tumor cells: a report of three cases with immunoperoxidase study. | journal = Cancer | volume = 47 | issue = 10 | pages = 2451-9 | month = May | year = 1981 | doi =  | PMID = 7023643 }}</ref>
* Adipocyte-like maturation <ref>{{Cite journal  | last1 = Rickert | first1 = CH. | last2 = Riemenschneider | first2 = MJ. | last3 = Schachenmayr | first3 = W. | last4 = Richter | first4 = HP. | last5 = Bockhorn | first5 = J. | last6 = Reifenberger | first6 = G. | last7 = Paulus | first7 = W. | title = Glioblastoma with adipocyte-like tumor cell differentiation--histological and molecular features of a rare differentiation pattern. | journal = Brain Pathol | volume = 19 | issue = 3 | pages = 431-8 | month = Jul | year = 2009 | doi = 10.1111/j.1750-3639.2008.00199.x | PMID = 18691268 }}</ref>
* Rhabdoid glioblastoma (focal loss of [[INI-1]]) <ref>{{Cite journal  | last1 = Hiroyuki | first1 = M. | last2 = Ogino | first2 = J. | last3 = Takahashi | first3 = A. | last4 = Hasegawa | first4 = T. | last5 = Wakabayashi | first5 = T. | title = Rhabdoid glioblastoma: an aggressive variaty of astrocytic tumor. | journal = Nagoya J Med Sci | volume = 77 | issue = 1-2 | pages = 321-8 | month = Feb | year = 2015 | doi =  | PMID = 25797998 }}</ref>
* Melanotic glioblastoma <ref>{{Cite journal  | last1 = Jaiswal | first1 = S. | last2 = Agrawal | first2 = V. | last3 = Vij | first3 = M. | last4 = Sahu | first4 = RN. | last5 = Jaiswal | first5 = AK. | last6 = Behari | first6 = S. | title = Glioblastoma with melanotic differentiation. | journal = Clin Neuropathol | volume = 29 | issue = 5 | pages = 330-3 | month =  | year =  | doi =  | PMID = 20860897 }}</ref>
* Glioblastoma with oligodendroglial component (no improved survival) <ref>{{Cite journal  | last1 = Hegi | first1 = ME. | last2 = Janzer | first2 = RC. | last3 = Lambiv | first3 = WL. | last4 = Gorlia | first4 = T. | last5 = Kouwenhoven | first5 = MC. | last6 = Hartmann | first6 = C. | last7 = von Deimling | first7 = A. | last8 = Martinet | first8 = D. | last9 = Besuchet Schmutz | first9 = N. | title = Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial. | journal = Acta Neuropathol | volume = 123 | issue = 6 | pages = 841-52 | month = Jun | year = 2012 | doi = 10.1007/s00401-011-0938-4 | PMID = 22249618 }}</ref>
*Granular cell Glioblastoma <ref>{{Cite journal  | last1 = Schittenhelm | first1 = J. | last2 = Psaras | first2 = T. | title = Glioblastoma with granular cell astrocytoma features: a case report and literature review. | journal = Clin Neuropathol | volume = 29 | issue = 5 | pages = 323-9 | month =  | year =  | doi =  | PMID = 20860896 }}</ref>
*Glioblastoma with PNET component <ref>{{Cite journal  | last1 = Perry | first1 = A. | last2 = Miller | first2 = CR. | last3 = Gujrati | first3 = M. | last4 = Scheithauer | first4 = BW. | last5 = Zambrano | first5 = SC. | last6 = Jost | first6 = SC. | last7 = Raghavan | first7 = R. | last8 = Qian | first8 = J. | last9 = Cochran | first9 = EJ. | title = Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. | journal = Brain Pathol | volume = 19 | issue = 1 | pages = 81-90 | month = Jan | year = 2009 | doi = 10.1111/j.1750-3639.2008.00167.x | PMID = 18452568 }}</ref>
*Small cell glioblastoma.
*Ependymal-like growth patterns.


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