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Difference between revisions of "Glioblastoma"
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*Median survival is measured in months.<ref>{{Cite journal | last1 = Jubelirer | first1 = SJ. | title = A review of the treatment and survival rates of 138 patients with glioblastoma multiforme. | journal = W V Med J | volume = 92 | issue = 4 | pages = 186-90 | month = | year = | doi = | PMID = 8772403 }}</ref> | *Median survival is measured in months.<ref>{{Cite journal | last1 = Jubelirer | first1 = SJ. | title = A review of the treatment and survival rates of 138 patients with glioblastoma multiforme. | journal = W V Med J | volume = 92 | issue = 4 | pages = 186-90 | month = | year = | doi = | PMID = 8772403 }}</ref> | ||
*Only about 5% can expect to survive more than three years.<ref name=pmid17785346>{{Cite journal | last1 = Krex | first1 = D. | last2 = Klink | first2 = B. | last3 = Hartmann | first3 = C. | last4 = von Deimling | first4 = A. | last5 = Pietsch | first5 = T. | last6 = Simon | first6 = M. | last7 = Sabel | first7 = M. | last8 = Steinbach | first8 = JP. | last9 = Heese | first9 = O. | title = Long-term survival with glioblastoma multiforme. | journal = Brain | volume = 130 | issue = Pt 10 | pages = 2596-606 | month = Oct | year = 2007 | doi = 10.1093/brain/awm204 | PMID = 17785346 }}</ref> | *Only about 5% can expect to survive more than three years.<ref name=pmid17785346>{{Cite journal | last1 = Krex | first1 = D. | last2 = Klink | first2 = B. | last3 = Hartmann | first3 = C. | last4 = von Deimling | first4 = A. | last5 = Pietsch | first5 = T. | last6 = Simon | first6 = M. | last7 = Sabel | first7 = M. | last8 = Steinbach | first8 = JP. | last9 = Heese | first9 = O. | title = Long-term survival with glioblastoma multiforme. | journal = Brain | volume = 130 | issue = Pt 10 | pages = 2596-606 | month = Oct | year = 2007 | doi = 10.1093/brain/awm204 | PMID = 17785346 }}</ref> | ||
==Macroscopy== | |||
Features: | |||
* Usu. in white matter. | |||
** central necrotic core. | |||
** ill-defined borders. | |||
** yellowish to dark-brown changes. | |||
** midline shift due to tumor mass. | |||
* In the corpus callosum as bihemispheric "butterfly glioma" | |||
<gallery> | |||
File:Glioblastoma multiforme - MRT T1KM ax.jpg | Ring-enhancement in GBM (WC/Hellerhoff) | |||
File:Glioblastoma macro.jpg | Left insular GBM macroscopy (WC/Sbrandner) | |||
File:Glioblastoma multiforme.jpg | "Butterfly glioma" (WC/AFIP) | |||
</gallery> | |||
==Microscopic== | ==Microscopic== | ||
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File:Wilms tumor protein wt1 immunohistocehmistry glioblastoma.JPG | WT1 immunostaining in GBM (WC/jensflorian) | File:Wilms tumor protein wt1 immunohistocehmistry glioblastoma.JPG | WT1 immunostaining in GBM (WC/jensflorian) | ||
File:Glioblastoma P53.jpg | GBM with strong p53 immunreactivity (WC/jensflorian) | File:Glioblastoma P53.jpg | GBM with strong p53 immunreactivity (WC/jensflorian) | ||
File:IDH1 GBM 20x.jpg | IDH1 R132H immunreactivity in a secondary GBM (WC/Marvin101) | |||
</gallery> | </gallery> | ||