Difference between revisions of "Parathyroid hyperplasia"
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Revision as of 04:53, 10 December 2015
Parathyroid hyperplasia is an abnormal proliferation of the parathyroid glands and a relatively common cause of hyperparathyroidism that is typically associated with chronic renal failure.[1]
General
- Common cause of hyperparathyroidism.
- Usually associated with chronic renal failure.
- May be syndromic - chief cell hyperplasia - associated with MEN 1, MEN 2A.[2]
Gross
- Classically all parathyroid glands are involved; however, some may be spared making it difficult to differentiate this from parathyroid adenoma.[3]
Microscopic
Features:[3]
- Classically have abundant adipose tissue.
- +/-Water-clear cells ("water-clear cell hyperplasia").
Note:
- Generally, it is impossible to discern between parathyroid adenomas and parathyroid hyperplasias by histology alone.[4]
- One requires information of the size of the other glands to make the diagnosis.
DDx:
- Parathyroid adenoma - classically have a rim of normal parathyroid gland around it.
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Clinical history is suggestive
A. Right Superior Parathyroid, Excision: - Parathyroid tissue compatible with hyperplasia. B. Right Inferior Parathyroid, Excision: - Parathyroid tissue compatible with hyperplasia. C. Portion of Left Inferior Parathyroid, Excision: - Parathyroid tissue compatible with hyperplasia. D. Left Superior Parathyroid, Excision: - Parathyroid tissue compatible with hyperplasia.
See also
References
- ↑ Jamal, SA.; Miller, PD.. "Secondary and tertiary hyperparathyroidism.". J Clin Densitom 16 (1): 64-8. doi:10.1016/j.jocd.2012.11.012. PMID 23267748.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970475-2. Accessed on: 29 July 2010.
- ↑ 3.0 3.1 Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1128. ISBN 978-1416031215.
- ↑ Taxy, J.; Husain, A; Montag, A. (2009). Biopsy Interpretation: The Frozen Section (1st ed.). Lippincott Williams & Wilkins. pp. 191. ISBN 978-0781767798.