49,267
edits
Difference between revisions of "Ewing sarcoma"
Jump to navigation
Jump to search
no edit summary
(wikify) |
|||
| (6 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Ewing sarcoma - PAS - high mag.jpg | |||
| Width = | |||
| Caption = Ewing sarcoma. [[PAS stain]]. | |||
| Micro = [[small round cell tumour]], clear cytoplasm | |||
| Subtypes = | |||
| LMDDx = [[Ewing-like tumours]] (e.g. [[CIC-DUX sarcoma]]), [[small round cell tumours]] ([[lymphoma]], [[small cell osteosarcoma]], others) | |||
| Stains = [[PAS stain]] +ve, [[PASD stain]] -ve | |||
| IHC = [[CD99]] +ve, FLI-1 +ve, CD45 -ve | |||
| EM = | |||
| Molecular = EWS [[Chromosomal translocations|translocation]], EWS/FLI-1 fusion gene in 90% of cases | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]], rarely other sites | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usually <20 years old | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Ewing sarcoma''', also known as '''EWS/pPNET''', is an uncommon bone tumour. | '''Ewing sarcoma''', also known as '''EWS/pPNET''', is an uncommon bone tumour. | ||
| Line 10: | Line 39: | ||
*Usually younger than 20 years. | *Usually younger than 20 years. | ||
*Second most common malignant bone tumour in children. | *Second most common malignant bone tumour in children. | ||
**Most common malignant bone tumour = osteosarcoma (AKA osteogenic sarcoma). | **Most common malignant bone tumour = [[osteosarcoma]] ([[AKA]] ''osteogenic sarcoma''). | ||
Poor prognostic factors:<ref>PST. 14 February 2011.</ref> | Poor prognostic factors:<ref>PST. 14 February 2011.</ref> | ||
| Line 40: | Line 69: | ||
*It is a [[small round cell tumour]]. | *It is a [[small round cell tumour]]. | ||
*[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | *[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | ||
DDx: | |||
*[[Ewing-like tumours]] (e.g. [[CIC-DUX sarcoma]]). | |||
*Large cell [[lymphoma]]. | |||
*Other [[small round cell tumours]] (e.g. small cell [[osteosarcoma]]). | |||
====Images==== | ====Images==== | ||
| Line 62: | Line 96: | ||
*CD45 -ve. | *CD45 -ve. | ||
**Done to r/o [[lymphoma]]. | **Done to r/o [[lymphoma]]. | ||
*+/-Neural markers (NSE, synaptophysin, CD57 (??? CD56 ???), | *+/-Neural markers (NSE, synaptophysin, CD57 (??? CD56 ???), S-100). | ||
*+/-Cytokeratins. | *+/-Cytokeratins. | ||
*Caveolin-1 +ve in ~ 85% of EWS.<ref>PST. 14 February 2011.</ref> | *Caveolin-1 +ve in ~ 85% of EWS.<ref>PST. 14 February 2011.</ref> | ||
| Line 68: | Line 102: | ||
Notes:<ref>PST. 22 February 2010.</ref> | Notes:<ref>PST. 22 February 2010.</ref> | ||
*CD99 +ve | *[[CD99]] +ve | ||
**Plasma membrane staining tumours: | **Plasma membrane staining tumours: | ||
***[[Lymphoblastic lymphoma]]/leukemia. | ***[[Lymphoblastic lymphoma]]/leukemia. | ||