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Difference between revisions of "Pediatric pathology"
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→Juvenile xanthogranuloma
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===General=== | ===General=== | ||
*Benign skin thingy in children and infants. | *Benign skin thingy in children and infants. | ||
*Most common form of non–Langerhans cell histiocytosis.<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=emed_jxg>URL: [http://emedicine.medscape.com/article/1111629-diagnosis http://emedicine.medscape.com/article/1111629-diagnosis]. Accessed on: 3 February 2011.</ref> | ||
*Dermal histiocytes: | *Dermal histiocytes: | ||
**Abundant cytoplasm - may not be xanthomatous. | **Abundant cytoplasm - may not be xanthomatous/foam cells. | ||
*+/-Touton giant cell - '''key feature'''. | *+/-Touton giant cell - '''key feature'''. | ||
**Large multi-nucleated cells where nuclei are distributed at the cell periphery. | |||
Images: | Images: | ||
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Notes: | Notes: | ||
*Must prove they are non-Langerhans cell histiocytes. | *Must prove they are non-Langerhans cell histiocytes, esp. if no Touton giant cells. | ||
===IHC=== | ===IHC=== | ||
*Langerhans cell markers: CD1a, CD207 -- both should be negative -- | *Langerhans cell markers: CD1a, CD207 -- both should be negative. | ||
**If Touton giant cells are absent -- this is essential. | |||
*Histiocyte markers: CD68, CD163 -- both should be positive. | *Histiocyte markers: CD68, CD163 -- both should be positive. | ||