Difference between revisions of "Post-infectious glomerulonephritis"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Post-infectious_glomerulonephritis_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Post-infectious glomerulonephritis. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = +/-neutrophils in glomerulus, [[glomerular crescents]] | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = subepithelial deposits, hump-like | |||
| Molecular = | |||
| IF = granular immune deposits | |||
| Gross = | |||
| Grossing = | |||
| Site = [[kidney]] - see ''[[medical kidney diseases]]'' | |||
| Assdx = post-infection, e.g. [[pneumonia]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = [[nephritic syndrome]] (proteinuria, [[hypertension]], azotemia, [[RBC]] casts, oliguria, hematuria) | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = usually good | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Post-infectious glomerulonephritis''', abbreviated '''PIGN''', is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection. | '''Post-infectious glomerulonephritis''', abbreviated '''PIGN''', is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection. | ||
==General== | ==General== | ||
*Classically post-streptococcal infection. | *Classically post-streptococcal infection.<ref name=pmid12746805>{{Cite journal | last1 = Barbiano Di Belgiojoso | first1 = G. | last2 = Genderini | first2 = A. | last3 = Ferrario | first3 = F. | title = [Post-infectious glomerulonephritis]. | journal = G Ital Nefrol | volume = 20 | issue = 2 | pages = 184-99 | month = | year = | doi = | PMID = 12746805 }}</ref><ref name=pmid24777751/> | ||
**Lab test: Antistreptolysin O titer (ASOT) +ve. | **Lab test: Antistreptolysin O titer (ASOT) +ve. | ||
Clinical: | |||
*[[Nephritic syndrome]].<ref name=pmid24777751>{{Cite journal | last1 = Stratta | first1 = P. | last2 = Musetti | first2 = C. | last3 = Barreca | first3 = A. | last4 = Mazzucco | first4 = G. | title = New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium. | journal = J Nephrol | volume = 27 | issue = 3 | pages = 229-39 | month = Jun | year = 2014 | doi = 10.1007/s40620-013-0018-z | PMID = 24777751 }}</ref> | |||
==Microscopic== | ==Microscopic== | ||
| Line 23: | Line 57: | ||
==EM== | ==EM== | ||
*Subepithelial deposits - hump-like. | *Subepithelial deposits - hump-like.<ref name=pmid18162726>{{Cite journal | last1 = Sung | first1 = HY. | last2 = Lim | first2 = CH. | last3 = Shin | first3 = MJ. | last4 = Kim | first4 = BS. | last5 = Kim | first5 = YO. | last6 = Song | first6 = HC. | last7 = Kim | first7 = SY. | last8 = Choi | first8 = EJ. | last9 = Chang | first9 = YS. | title = A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage. | journal = J Korean Med Sci | volume = 22 | issue = 6 | pages = 1074-8 | month = Dec | year = 2007 | doi = | PMID = 18162726 }}</ref> | ||
**Larger when measured perpendicular to the basement membrane, if compared to [[membranous nephropathy]]. | **Larger when measured perpendicular to the basement membrane, if compared to [[membranous nephropathy]]. | ||
**Typically focal. | **Typically focal. | ||
| Line 34: | Line 68: | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Medical kidney | [[Category:Medical kidney pathology]] | ||
Latest revision as of 06:24, 11 April 2015
| Post-infectious glomerulonephritis | |
|---|---|
| Diagnosis in short | |
 Post-infectious glomerulonephritis. H&E stain. | |
|
| |
| LM | +/-neutrophils in glomerulus, glomerular crescents |
| EM | subepithelial deposits, hump-like |
| IF | granular immune deposits |
| Site | kidney - see medical kidney diseases |
|
| |
| Associated Dx | post-infection, e.g. pneumonia |
| Signs | nephritic syndrome (proteinuria, hypertension, azotemia, RBC casts, oliguria, hematuria) |
| Prevalence | uncommon |
| Prognosis | usually good |
Post-infectious glomerulonephritis, abbreviated PIGN, is a rarely biopsied glomerulonephritis classically associated with a streptococcal infection.
General
Clinical:
Microscopic
Features:
- +/-Neutrophils - in glomerulus.
- Glomerular crescents.
Images
Post-infectious GN - high mag. (WC/Nephron)
Post-infectious GN - very high mag. (WC/Nephron)
Post-infectious GN - schematic (WC/Nephron)
www:
IF
- Granular immune deposits.
EM
- Subepithelial deposits - hump-like.[3]
- Larger when measured perpendicular to the basement membrane, if compared to membranous nephropathy.
- Typically focal.
See also
References
- ↑ Barbiano Di Belgiojoso, G.; Genderini, A.; Ferrario, F.. "[Post-infectious glomerulonephritis].". G Ital Nefrol 20 (2): 184-99. PMID 12746805.
- ↑ 2.0 2.1 Stratta, P.; Musetti, C.; Barreca, A.; Mazzucco, G. (Jun 2014). "New trends of an old disease: the acute post infectious glomerulonephritis at the beginning of the new millenium.". J Nephrol 27 (3): 229-39. doi:10.1007/s40620-013-0018-z. PMID 24777751.
- ↑ Sung, HY.; Lim, CH.; Shin, MJ.; Kim, BS.; Kim, YO.; Song, HC.; Kim, SY.; Choi, EJ. et al. (Dec 2007). "A case of post-streptococcal glomerulonephritis with diffuse alveolar hemorrhage.". J Korean Med Sci 22 (6): 1074-8. PMID 18162726.