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Difference between revisions of "Thyroid gland"
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=Thyroid specimens= | =Thyroid specimens= | ||
They come in 3 common varieties | ==They come in 3 common varieties== | ||
*Hemithyroid. | *Hemithyroid. | ||
**Done to get a definitive diagnosis. | **Done to get a definitive diagnosis. | ||
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**done to r/o malignancy. | **done to r/o malignancy. | ||
Gross pathology | ==Gross pathology== | ||
*White nodules - think: | *White nodules - think: | ||
**Lymphoid tissue. | **Lymphoid tissue. | ||
| Line 35: | Line 35: | ||
*Thick capsule. | *Thick capsule. | ||
*Necrosis - rare in the thyroid. | *Necrosis - rare in the thyroid. | ||
==Thyroid IHC - general comments== | |||
*Not really useful. | |||
*Papers with very small sample sizes abound. | |||
===Follicular thyroid carcinoma vs. papillary thyroid carcinoma=== | |||
*CD31 more frequently positive in follicular lesions.<ref name=pmid18795075>{{Cite journal | last1 = Rydlova | first1 = M. | last2 = Ludvikova | first2 = M. | last3 = Stankova | first3 = I. | title = Potential diagnostic markers in nodular lesions of the thyroid gland: an immunohistochemical study. | journal = Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub | volume = 152 | issue = 1 | pages = 53-9 | month = Jun | year = 2008 | doi = | PMID = 18795075 }}</ref> | |||
**CD31 is a marker for microvessel density. | |||
*Galectin-3 thought to be positive in papillary carcinoma.<ref name=pmid18795075/> | |||
*HBME-1 thought to be positive in papillary lesions.<ref name=pmid15529186>{{Cite journal | last1 = Papotti | first1 = M. | last2 = Rodriguez | first2 = J. | last3 = De Pompa | first3 = R. | last4 = Bartolazzi | first4 = A. | last5 = Rosai | first5 = J. | title = Galectin-3 and HBME-1 expression in well-differentiated thyroid tumors with follicular architecture of uncertain malignant potential. | journal = Mod Pathol | volume = 18 | issue = 4 | pages = 541-6 | month = Apr | year = 2005 | doi = 10.1038/modpathol.3800321 | PMID = 15529186 }}</ref> | |||
=Parathyroid tissue= | =Parathyroid tissue= | ||
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*TTF-1 +ve. | *TTF-1 +ve. | ||
== | ==Lymphomas of the thyroid== | ||
{{Main|Lymphoma}} | |||
===General=== | |||
*Rare. | |||
=== | *Increased risk with chronic inflammatory conditions. | ||
* | *Fit in the the greater category of ''[[MALT lymphoma]]''. | ||
* | |||
* | ===Microscopic=== | ||
* | Features: | ||
*Lymphoepithelial lesion - '''key feature'''. | |||
*Plasma cells. | |||
*"Overgrowth" - thyroid parenchyma displaced by lymphocytes. | |||
=See also= | =See also= | ||