Difference between revisions of "Angiosarcoma"

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| IHC        = CD31 +ve, FLI-1 +ve, CD34 +ve, HHV-8 -ve
| IHC        = CD31 +ve, FLI-1 +ve, CD34 +ve, HHV-8 -ve
| EM        =
| EM        =
| Molecular  =
| Molecular  = +/-MYC amplification
| IF        =
| IF        =
| Gross      = red lesion{{fact}}
| Gross      = red lesion{{fact}}
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*D2-40 +ve/-ve.<ref name=pmid11950918>{{Cite journal  | last1 = Kahn | first1 = HJ. | last2 = Bailey | first2 = D. | last3 = Marks | first3 = A. | title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. | journal = Mod Pathol | volume = 15 | issue = 4 | pages = 434-40 | month = Apr | year = 2002 | doi = 10.1038/modpathol.3880543 | PMID = 11950918 | URL = http://www.nature.com/modpathol/journal/v15/n4/full/3880543a.html }}</ref>
*D2-40 +ve/-ve.<ref name=pmid11950918>{{Cite journal  | last1 = Kahn | first1 = HJ. | last2 = Bailey | first2 = D. | last3 = Marks | first3 = A. | title = Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. | journal = Mod Pathol | volume = 15 | issue = 4 | pages = 434-40 | month = Apr | year = 2002 | doi = 10.1038/modpathol.3880543 | PMID = 11950918 | URL = http://www.nature.com/modpathol/journal/v15/n4/full/3880543a.html }}</ref>
*HHV-8 -ve.
*HHV-8 -ve.
==Molecular==
*Amplification of MYC<ref name=pmid25374893>{{Cite journal  | last1 = Kurisetty | first1 = V. | last2 = Bryan | first2 = BA. | title = Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of Angiosarcoma. | journal = Angiol Open Access | volume = 1 | issue =  | pages =  | month = Apr | year = 2013 | doi = 10.4172/2329-9495.1000102 | PMID = 25374893 }}</ref> - esp. in secondary angiosarcoma.<ref name=pmid24983371>{{Cite journal  | last1 = Styring | first1 = E. | last2 = Seinen | first2 = J. | last3 = Dominguez-Valentin | first3 = M. | last4 = Domanski | first4 = HA. | last5 = Jönsson | first5 = M. | last6 = von Steyern | first6 = FV. | last7 = Hoekstra | first7 = HJ. | last8 = Suurmeijer | first8 = AJ. | last9 = Nilbert | first9 = M. | title = Key roles for MYC, KIT and RET signaling in secondary angiosarcomas. | journal = Br J Cancer | volume = 111 | issue = 2 | pages = 407-12 | month = Jul | year = 2014 | doi = 10.1038/bjc.2014.359 | PMID = 24983371 }}</ref>


==See also==
==See also==

Revision as of 06:12, 9 November 2014

Angiosarcoma
Diagnosis in short

Epithelioid angiosarcoma. H&E stain.

LM atypical cells - usu. spindle cells, occasionally epithelioid; vascular differentiation (abundant capillaries - "red" at low power, +/-cytoplasmic vacuolization, +/-hobnail endothelial cells)
LM DDx Kaposi sarcoma, other vascular tumours
IHC CD31 +ve, FLI-1 +ve, CD34 +ve, HHV-8 -ve
Molecular +/-MYC amplification
Gross red lesion[citation needed]
Site skin, head and neck, elsewhere

Syndromes Stewart–Treves syndrome

Clinical history +/-chronic lymphedema, vinyl chloride exposure (liver angiosarcoma)
Prevalence uncommon
Prognosis poor

Angiosarcoma is an uncommon malignant vascular tumour.

General

  • Malignant tumour - general has a poor prognosis.[1]

Epidemiology:

  • May arise secondary to chronic lymphedema related to breast carcinoma.
    • Known as Stewart–Treves syndrome.[2]
  • Liver angiosarcomas are associated with vinyl chloride exposure.[3]
  • Cutaneous angiosarcomas are classically seen on the head and neck of whites over 60 years old.[4]

Microscopic

Features:

  • Spindle cell lesion.
    • Occasionally an epithelioid lesion.
  • Very many small capillaries of irregular shape lined with:
    • Pleomorphic nuclei - important.
      • May have hobnail morphology.
    • Usually "red" at low power - due to many RBCs - important.
  • Mitoses.
  • Cytoplasmic vacuoles.
    • Cells trying to form lumina - embryologic.

Notes:

DDx:

Images

IHC

  • CD34 +ve.
  • CD31 +ve.
  • FLI-1 +ve.[5]
  • D2-40 +ve/-ve.[6]
  • HHV-8 -ve.

Molecular

  • Amplification of MYC[7] - esp. in secondary angiosarcoma.[8]

See also

References

  1. Young RJ, Brown NJ, Reed MW, Hughes D, Woll PJ (May 2010). "Angiosarcoma". Lancet Oncol. doi:10.1016/S1470-2045(10)70023-1. PMID 20537949.
  2. Pincus, LB.; Fox, LP. (Aug 2008). "Images in clinical medicine. The Stewart-Treves syndrome.". N Engl J Med 359 (9): 950. doi:10.1056/NEJMicm071344. PMID 18753651. http://www.nejm.org/doi/full/10.1056/NEJMicm071344.
  3. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 212. ISBN 978-1416054542.
  4. Albores-Saavedra, J.; Schwartz, AM.; Henson, DE.; Kostun, L.; Hart, A.; Angeles-Albores, D.; Chablé-Montero, F. (Apr 2011). "Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007.". Ann Diagn Pathol 15 (2): 93-7. doi:10.1016/j.anndiagpath.2010.07.012. PMID 21190880.
  5. Rossi, S.; Orvieto, E.; Furlanetto, A.; Laurino, L.; Ninfo, V.; Dei Tos, AP. (May 2004). "Utility of the immunohistochemical detection of FLI-1 expression in round cell and vascular neoplasm using a monoclonal antibody.". Mod Pathol 17 (5): 547-52. doi:10.1038/modpathol.3800065. PMID 15001993.
  6. Kahn, HJ.; Bailey, D.; Marks, A. (Apr 2002). "Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas.". Mod Pathol 15 (4): 434-40. doi:10.1038/modpathol.3880543. PMID 11950918.
  7. Kurisetty, V.; Bryan, BA. (Apr 2013). "Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of Angiosarcoma.". Angiol Open Access 1. doi:10.4172/2329-9495.1000102. PMID 25374893.
  8. Styring, E.; Seinen, J.; Dominguez-Valentin, M.; Domanski, HA.; Jönsson, M.; von Steyern, FV.; Hoekstra, HJ.; Suurmeijer, AJ. et al. (Jul 2014). "Key roles for MYC, KIT and RET signaling in secondary angiosarcomas.". Br J Cancer 111 (2): 407-12. doi:10.1038/bjc.2014.359. PMID 24983371.