Difference between revisions of "Endometrial hyperplasia"

Endometrial hyperplasia (view source)

1,286 bytes removed , 14:48, 15 May 2014

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 ==Simple endometrial hyperplasia with atypia==
-===General===
+{{Main|Simple endometrial hyperplasia}}
-*Very uncommon.
-===Microscopic===
-Features:<ref name=Ref_GP236>{{Ref GP|236}}</ref>
-*Irregular dilated glands (with large lumens) - '''important feature'''.
-**Glands described as "animal shapes".
-*Variation of gland size.
-*No nuclear atypia.
-**Uniform columnar nuclei.
-*Normal gland density (gland area in plane of section/total area ~= 1/3).
-*Nuclear atypia:<ref>{{Cite journal  | last1 = Silverberg | first1 = SG. | title = Problems in the differential diagnosis of endometrial hyperplasia and carcinoma. | journal = Mod Pathol | volume = 13 | issue = 3 | pages = 309-27 | month = Mar | year = 2000 | doi = 10.1038/modpathol.3880053 | PMID = 10757341 }}</ref>
-**Loss of basal nuclear stratification.
-**Nuclear size variation.
-**Nuclear rounding.
-***Nuclei lacking atypical = uniform columnar nuclei.
-**Nucleoli.
-**Hyperchromasia or vesicular nuclei.
-Notes:
-*There are no clear criteria for atypia. Different sources list different features.
-*VL criteria for atypia (all should be present):
-*#Increased NC ratio.
-*#*Atypical: ~ 1:2
-*#*Not atypical: ~1:3.
-*#Oval nuclei with small major axis to minor axis ratio.
-*#*Atypical: major axis:minor axis = <=2:1.
-*#*Not atypical: major axis:minor axis = >=3:1
-*#**NB: round nuclei: major axis:minor axis = 1:1.
-*#Small nucleoli (~1/5 the size of the nucleus).
 ==Complex endometrial hyperplasia==