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Difference between revisions of "Collagenous spherulosis"
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Collagenous spherulosis (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Collagenous_spherulosis_-_very_high_mag.jpg | |||
| Width = | |||
| Caption = Collagenous spherulosis. [[H&E stain]]. | |||
| Synonyms = mucinous spherulosis, spherulosis | |||
| Micro = tubular/cribriform architecture with intratubular eosinophilic material (classical arranged like the spokes of a wheel ("radial spikes"), granules ~ 1-2 micrometers), | |||
no mitotic activity, epithelial & myoepithelial - like benign breast | |||
| Subtypes = | |||
| LMDDx = [[atypical ductal hyperplasia]], [[cribriform DCIS]], [[adenoid cystic carcinoma of the breast]] | |||
| Stains = | |||
| IHC = CD10 +ve, ER +ve, PR +ve, p63 +ve, SMA +ve, CD117 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[breast]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = usu. asymptomatic | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = none required, usu. incidental finding | |||
}} | |||
'''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy. | '''Collagenous spherulosis''' is a benign change of the [[breast]] that can be confused for a malignancy. | ||
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www: | www: | ||
*[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)]. | *[http://www.hsc.stonybrook.edu/breast-atlas/V-33.htm Collagenous spherulosis (stonybrook.edu)]. | ||
==IHC== | |||
Features:<ref name=pmid22658481>{{Cite journal | last1 = Cabibi | first1 = D. | last2 = Giannone | first2 = AG. | last3 = Belmonte | first3 = B. | last4 = Aragona | first4 = F. | last5 = Aragona | first5 = F. | title = CD10 and HHF35 actin in the differential diagnosis between Collagenous spherulosis and adenoid-cystic carcinoma of the breast. | journal = Pathol Res Pract | volume = 208 | issue = 7 | pages = 405-9 | month = Jul | year = 2012 | doi = 10.1016/j.prp.2012.05.002 | PMID = 22658481 }}</ref> | |||
*CD10 +ve. ‡ | |||
*Muscle-specific actin +ve. ‡ | |||
*ER +ve. ‡ | |||
*PR +ve. ‡ | |||
*CD117 -ve. ‡ | |||
Others:<ref name=pmid22658481/> | |||
*SMA +ve. | |||
*p63 +ve. | |||
*CK 5/6 +ve. | |||
Note: | |||
* ‡ The opposite pattern is seen in ''adenoid cystic carcinoma''. | |||
==See also== | ==See also== | ||
*[[Breast pathology]]. | *[[Breast pathology]]. | ||
*[[Adenoid cystic carcinoma]]. | |||
==References== | ==References== | ||