Difference between revisions of "Adenomyoepithelioma"

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#redirect [[Breast_pathology#Adenomyoepithelioma]]
'''Adenomyoepithelioma''' is an uncommon pathology of the [[breast]]. It is usually benign.
 
==General==
*Rare lesion consisting of epithelial and myoepithelial elements.
**May occur in other sites, e.g. tonsil.<ref name=pmid20356364>{{Cite journal  | last1 = Ren | first1 = J. | last2 = Song | first2 = L. | last3 = Dang | first3 = Q. | last4 = Zhang | first4 = X. | last5 = Jiang | first5 = SW. | last6 = Zhang | first6 = G. | last7 = Wang | first7 = N. | last8 = Liu | first8 = Z. | last9 = Wang | first9 = J. | title = Primary adenomyoepithelioma of tonsil. | journal = Head Neck Oncol | volume = 2 | issue =  | pages = 7 | month =  | year = 2010 | doi = 10.1186/1758-3284-2-7 | PMID = 20356364 }}</ref>
*May be benign or malignant.<ref name=pmid12591699>{{Cite journal  | last1 = Howlett | first1 = DC. | last2 = Mason | first2 = CH. | last3 = Biswas | first3 = S. | last4 = Sangle | first4 = PD. | last5 = Rubin | first5 = G. | last6 = Allan | first6 = SM. | title = Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology. | journal = AJR Am J Roentgenol | volume = 180 | issue = 3 | pages = 799-803 | month = Mar | year = 2003 | doi =  | PMID = 12591699 | url=http://www.ajronline.org/content/180/3/799.full}}</ref><ref name=pmid19480267>{{Cite journal  | last1 = Zizi-Sermpetzoglou | first1 = A. | last2 = Vasilakaki | first2 = T. | last3 = Grammatoglou | first3 = X. | last4 = Petrakopoulou | first4 = N. | last5 = Nikolaidou | first5 = ME. | last6 = Glava | first6 = C. | title = Malignant adenomyoepithelioma of the breast--case report. | journal = Eur J Gynaecol Oncol | volume = 30 | issue = 2 | pages = 234-6 | month =  | year = 2009 | doi =  | PMID = 19480267 }}</ref>
 
Note:
*Possibly the same tumour as [[epithelial-myoepithelial carcinoma]] of the [[salivary gland]].<ref name=pmid9769134>{{Cite journal  | last1 = Seifert | first1 = G. | title = Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours? | journal = Virchows Arch | volume = 433 | issue = 3 | pages = 285-8 | month = Sep | year = 1998 | doi =  | PMID = 9769134 }}</ref>
 
==Microscopic==
Features:<ref>URL: [http://www.webpathology.com/image.asp?n=1&Case=322 http://www.webpathology.com/image.asp?n=1&Case=322]. Accessed on: 16 August 2011.</ref>
*Well-circumscribed.
*Glandular architecture with:
**Easily identifiable myoepithelial cells - with clear cytoplasm - '''key feature'''.
**Eosinophilic cuboidal epithelial cells.
*Eosinophilic basement membrane material between glands.
 
DDx:
*[[Invasive ductal carcinoma of the breast]] (on core biopsy).
*Mammary pleomorphic adenoma.
*Ductal adenoma.
*[[Tubular adenoma of the breast]] - does not have a prominent (clear) myoepithelial component.
*[[Sclerosing adenosis]].<ref name=chu>Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: [http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf]. Accessed on: 28 April 2012.</ref>
 
===Images===
<gallery>
Image:Adenomyoepithelioma_-_low_mag.jpg | Adenomyoepithelioma - low mag. (WC/Nephron)
Image:Adenomyoepithelioma_-_intermed_mag.jpg | Adenomyoepithelioma - intermed. mag. (WC/Nephron)
Image:Adenomyoepithelioma_-_high_mag.jpg | Adenomyoepithelioma - high mag. (WC/Nephron)
</gallery>
 
Webpathology.com:
*[http://www.webpathology.com/image.asp?n=1&Case=322 Adenomyoepithelioma - low mag. (webpathology.com)].
*[http://www.webpathology.com/image.asp?n=4&Case=322 Adenomyoepithelioma - high mag. (webpathology.com)].
 
==See also==
*[[Breast pathology]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Breast pathology]]

Revision as of 18:41, 16 February 2014

Adenomyoepithelioma is an uncommon pathology of the breast. It is usually benign.

General

  • Rare lesion consisting of epithelial and myoepithelial elements.
    • May occur in other sites, e.g. tonsil.[1]
  • May be benign or malignant.[2][3]

Note:

Microscopic

Features:[5]

  • Well-circumscribed.
  • Glandular architecture with:
    • Easily identifiable myoepithelial cells - with clear cytoplasm - key feature.
    • Eosinophilic cuboidal epithelial cells.
  • Eosinophilic basement membrane material between glands.

DDx:

Images

  • Adenomyoepithelioma - low mag. (WC/Nephron)

  • Adenomyoepithelioma - intermed. mag. (WC/Nephron)

  • Adenomyoepithelioma - high mag. (WC/Nephron)

Webpathology.com:

See also

References

  1. ↑ Ren, J.; Song, L.; Dang, Q.; Zhang, X.; Jiang, SW.; Zhang, G.; Wang, N.; Liu, Z. et al. (2010). "Primary adenomyoepithelioma of tonsil.". Head Neck Oncol 2: 7. doi:10.1186/1758-3284-2-7. PMID 20356364.
  2. ↑ Howlett, DC.; Mason, CH.; Biswas, S.; Sangle, PD.; Rubin, G.; Allan, SM. (Mar 2003). "Adenomyoepithelioma of the breast: spectrum of disease with associated imaging and pathology.". AJR Am J Roentgenol 180 (3): 799-803. PMID 12591699. http://www.ajronline.org/content/180/3/799.full.
  3. ↑ Zizi-Sermpetzoglou, A.; Vasilakaki, T.; Grammatoglou, X.; Petrakopoulou, N.; Nikolaidou, ME.; Glava, C. (2009). "Malignant adenomyoepithelioma of the breast--case report.". Eur J Gynaecol Oncol 30 (2): 234-6. PMID 19480267.
  4. ↑ Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
  5. ↑ URL: http://www.webpathology.com/image.asp?n=1&Case=322. Accessed on: 16 August 2011.
  6. ↑ Chu et al. (2006). Adenomyoepithelioma of the Breast — A Case Report. Tzu Chi Med J. Vol. 18 No. 1. URL:URL: http://www.tzuchi.com.tw/file/tcmj/95-1/2-8.pdf. Accessed on: 28 April 2012.
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