Difference between revisions of "Urothelium"

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*[[AKA]] ''papillary hyperplasia''.
*[[AKA]] ''papillary hyperplasia''.
*[[AKA]] ''reactive papillary hyperplasia''.
*[[AKA]] ''reactive papillary hyperplasia''.
===General===
{{Main|Papillary urothelial hyperplasia}}
*Benign.
*Strong association with papillary neoplasms.
**On follow-up, in one study, >1/3 have a neoplasm; thus, follow-up is recommended.<ref name=pmid20438409>{{Cite journal  | last1 = Readal | first1 = N. | last2 = Epstein | first2 = JI. | title = Papillary urothelial hyperplasia: relationship to urothelial neoplasms. | journal = Pathology | volume = 42 | issue = 4 | pages = 360-3 | month = Jun | year = 2010 | doi = 10.3109/00313021003767322 | PMID = 20438409 }}</ref>
 
===Microscopic===
Features:<ref>URL: [http://pathology.jhu.edu/bladder/definitions.cfm http://pathology.jhu.edu/bladder/definitions.cfm]. Accessed on: 27 January 2014.</ref>
*Inflammation.
*Rare papillae
**Do not have a well-developed fibrovascular core.
*No urothelial cell atypia.
 
Image:
*[http://pathology.jhu.edu/bladder/image1.cfm?case_number=2&image_number=1 Papillary hyperplasia (jhu.edu)].
 
===Sign out===
<pre>
URINARY BLADDER, BIOPSY:
- REACTIVE PAPILLARY HYPERPLASIA, SEE COMMENT.
- NO MUSCULARIS PROPRIA IDENTIFIED.
- CYSTITIS CYSTICA ET GLANDULARIS.
- NO EVIDENCE OF MALIGNANCY.
 
COMMENT:
The urothelial forms rare papillary structures; these are interpreted as reactive.
 
The urothelium stains as follow:
CK7: positive (patchy).
CK20: very rare superficial cells (normal).
Ki-67: rare, focally increased, negative in papillary structures (<10%).
p53: negative (weak focal <20%), very rare weak in rare papillary structures (<5%).
 
Follow-up is recommended.
</pre>


=Benign urothelial lesions=
=Benign urothelial lesions=
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