Difference between revisions of "Necrobiosis lipoidica"

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#redirect [[Non-malignant_skin_disease#Necrobiosis_lipoidica]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Necrobiosis_lipoidica_-_low_mag.jpg
| Width      =
| Caption    = Necrobiosis lipoidica. [[HPS stain]].
| Micro      = (dermal) palisading [[granuloma]] around necrotic collagen; little mucin; no normal dermis between foci; plasma cells - common;
+/-involve subcutis
| Subtypes  =
| LMDDx      = [[granuloma annulare]], [[rheumatoid nodule]]
| Stains    =
| IHC        =
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      =
| Assdx      = [[diabetes mellitus]], [[rheumatoid arthritis]]
| Syndromes  =
| Clinicalhx =
| Signs      =
| Symptoms  =
| Prevalence = uncommon
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  =
| Other      =
| ClinDDx    =
}}
'''Necrobiosis lipoidica''' is an uncommon granulomatous [[skin]] pathology.
 
==General==
Associated with:
*[[Diabetes mellitus]] - known as ''necrobiosis lipoidica diabeticorum''.
*[[Rheumatoid arthritis]].
 
==Gross==
 
Image:
<gallery>
Image:Necrobiosislipoidica.jpg | Necrobiosis lipoidica. (WC)
</gallery>
 
==Microscopic==
Features:<ref name=Ref_Derm51>{{Ref Derm|51}}</ref>
*Dermal palisading [[granuloma]] around:
**Necrotic collagen - '''key feature'''.
***Nuclei "missing" - have undergone karyolysis.
*Little mucin, no normal dermis between foci.
*Plasma cells - common.<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref>
*May involve adipose tissue.
 
DDx:
*[[Granuloma annulare|Granuloma a'''nn'''ulare]] - '''m'''ore '''m'''ucin, normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells uncommon,<ref name=dermnetnz_nl/> no fat involvement - usu. more superficial.
*[[Rheumatoid nodule]].
 
===Images===
<gallery>
Image:Necrobiosis_lipoidica_-_low_mag.jpg | Necrobiosis lipoidica - low mag. (WC)
</gallery>
www:
*[http://dermatology.cdlib.org/103/NYU/case_presentations/042004n10.html Necrobiosis lipoidica (dermatology.cdlib.org)].
*[http://www.drmihm.com/cases/case.cfm?CaseID=53 Necrobiosis lipoidica (drmihm.com)].
*[http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html Necrobiosis lipoidica (dermnetnz.org)].
 
==See also==
*[Non-malignant skin disease]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]

Revision as of 01:52, 31 October 2013

Necrobiosis lipoidica
Diagnosis in short

Necrobiosis lipoidica. HPS stain.
LM

(dermal) palisading granuloma around necrotic collagen; little mucin; no normal dermis between foci; plasma cells - common;

+/-involve subcutis
LM DDx granuloma annulare, rheumatoid nodule
Associated Dx diabetes mellitus, rheumatoid arthritis
Prevalence uncommon

Necrobiosis lipoidica is an uncommon granulomatous skin pathology.

General

Associated with:

Gross

Image:

  • Necrobiosis lipoidica. (WC)

Microscopic

Features:[1]

  • Dermal palisading granuloma around:
    • Necrotic collagen - key feature.
      • Nuclei "missing" - have undergone karyolysis.
  • Little mucin, no normal dermis between foci.
  • Plasma cells - common.[2]
  • May involve adipose tissue.

DDx:

Images

  • Necrobiosis lipoidica - low mag. (WC)

www:

See also

  • [Non-malignant skin disease]].

References

  1. ↑ 1.0 1.1 Busam, Klaus J. (2009). Dermatopathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Saunders. pp. 51. ISBN 978-0443066542.
  2. ↑ 2.0 2.1 URL: http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html. Accessed on: 24 January 2012.
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