Difference between revisions of "Solitary fibrous tumour"
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'''Solitary fibrous tumour''', abbreviated ''SFT'', is a type of [[soft tissue lesion|soft tissue tumour]] that fits in the [[fibroblastic/myofibroblastic tumours]]. It is usually benign. | |||
==General== | |||
*Grouped with ''hemangiopericytoma'' in the WHO classification - as it is thought to be the same tumour.<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref> | |||
*May be benign ''or'' malignant; more commonly benign.<ref>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9]. Accessed on: 25 June 2010.</ref><ref>URL: [http://wjso.com/content/6/1/86 http://wjso.com/content/6/1/86]. Accessed on: 25 June 2010.</ref> | |||
*May be associated with hypoglycemia. | |||
**Known as ''Doege-Potter syndrome''.<ref name=pmid1474302>{{Cite journal | last1 = Roy | first1 = TM. | last2 = Burns | first2 = MV. | last3 = Overly | first3 = DJ. | last4 = Curd | first4 = BT. | title = Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome. | journal = J Ky Med Assoc | volume = 90 | issue = 11 | pages = 557-60 | month = Nov | year = 1992 | doi = | PMID = 1474302 }}</ref> | |||
==Gross== | |||
*Classically arise from the pleura - see ''[[solitary fibrous tumour of the pleura]]''. | |||
==Microscopic== | |||
Features - benign: | |||
*Spindle cells in a patternless pattern. | |||
*Hemangiopericytoma-like area ([[staghorn vessels]]). | |||
*Keloid-like collagen bundles - '''key feature'''. | |||
*Usually well-circumscribed. | |||
Criteria for malignancy:<ref name=Ref_WMSP609>{{Ref WMSP|609}}</ref> | |||
*Necrosis. | |||
*Mitoses >4/10 HPF -- definition suffers from [[HPFitis]]. | |||
*Increased cellularity. | |||
*Marked nuclear atypia. | |||
*Infiltrative margin. | |||
===Images=== | |||
<gallery> | |||
Image:Solitary_fibrous_tumour_low_mag.jpg | Benign SFT - low mag. (WC) | |||
Image:Solitary_fibrous_tumour_intermed_mag.jpg | Benign SFT - intermed. mag. (WC) | |||
Image:Solitary_fibrous_tumour_high_mag.jpg | Benign SFT - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case272.html SFT of the brain - several images (upmc.edu)]. | |||
==IHC== | |||
*CD34 ~90% +ve. | |||
*CD99 ~70% +ve. | |||
*BCL2 ~50% +ve. | |||
==See also== | |||
*[[Fibroblastic/myofibroblastic tumours]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Fibroblastic/myofibroblastic tumours]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
Revision as of 23:25, 6 October 2013
Solitary fibrous tumour, abbreviated SFT, is a type of soft tissue tumour that fits in the fibroblastic/myofibroblastic tumours. It is usually benign.
General
- Grouped with hemangiopericytoma in the WHO classification - as it is thought to be the same tumour.[1]
- May be benign or malignant; more commonly benign.[2][3]
- May be associated with hypoglycemia.
- Known as Doege-Potter syndrome.[4]
Gross
- Classically arise from the pleura - see solitary fibrous tumour of the pleura.
Microscopic
Features - benign:
- Spindle cells in a patternless pattern.
- Hemangiopericytoma-like area (staghorn vessels).
- Keloid-like collagen bundles - key feature.
- Usually well-circumscribed.
Criteria for malignancy:[1]
- Necrosis.
- Mitoses >4/10 HPF -- definition suffers from HPFitis.
- Increased cellularity.
- Marked nuclear atypia.
- Infiltrative margin.
Images
Benign SFT - low mag. (WC)
Benign SFT - intermed. mag. (WC)
Benign SFT - high mag. (WC)
www:
IHC
- CD34 ~90% +ve.
- CD99 ~70% +ve.
- BCL2 ~50% +ve.
See also
References
- ↑ 1.0 1.1 Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 609. ISBN 978-0781765275.
- ↑ URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970528-9. Accessed on: 25 June 2010.
- ↑ URL: http://wjso.com/content/6/1/86. Accessed on: 25 June 2010.
- ↑ Roy, TM.; Burns, MV.; Overly, DJ.; Curd, BT. (Nov 1992). "Solitary fibrous tumor of the pleura with hypoglycemia: the Doege-Potter syndrome.". J Ky Med Assoc 90 (11): 557-60. PMID 1474302.