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Giant cell tumour of bone (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Giant_cell_tumour_of_bone_-_high_mag.jpg | |||
| Width = | |||
| Caption = Giant cell tumour of bone. [[H&E stain]]. | |||
| Micro = giant cells (usu. with >10 in the plane of section), mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells | |||
| Subtypes = | |||
| LMDDx = other [[giant cell lesions]] | |||
| Stains = | |||
| IHC = p63 +ve (patchy) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]], epiphysis usually | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usu. young adults (20-45 years old) | |||
| Signs = +/-immobility | |||
| Symptoms = +/-pain | |||
| Prevalence = uncommon ~ 5% of primary bone tumours | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Giant cell tumour of bone''' is an uncommon [[bone]] tumour. | |||
==General== | |||
Features:<ref name=Ref_WMSP648>{{Ref WMSP|648}}</ref> | |||
*Approximately 5% of primary [[bone tumour]]s. | |||
*Typical age: 20-45 years. | |||
===Clinical=== | |||
*Location: growth plate of long bones.<ref name=pmid11501745>{{Cite journal | last1 = Wülling | first1 = M. | last2 = Engels | first2 = C. | last3 = Jesse | first3 = N. | last4 = Werner | first4 = M. | last5 = Delling | first5 = G. | last6 = Kaiser | first6 = E. | title = The nature of giant cell tumor of bone. | journal = J Cancer Res Clin Oncol | volume = 127 | issue = 8 | pages = 467-74 | month = Aug | year = 2001 | doi = | PMID = 11501745 }}</ref> | |||
**May present with joint pain, immobility. | |||
Note: | |||
*Several types of [[giant cell lesions|giant cell tumours]] exist. | |||
==Microscopic== | |||
Features:<ref name=Ref_Klatt420>{{Ref Klatt|420}}</ref> | |||
*Giant cells with a large number of nuclei (usu. >10 in the plane of section). | |||
**Usu. have [[prominent nucleoli]]. | |||
*Mononuclear cells and small multinucleated cells with nuclei similar to those in the giant cells - '''key feature'''. | |||
*+/-Hemosiderin deposition - not common.<ref name=pmid1939753>{{Cite journal | last1 = Aoki | first1 = J. | last2 = Moriya | first2 = K. | last3 = Yamashita | first3 = K. | last4 = Fujioka | first4 = F. | last5 = Ishii | first5 = K. | last6 = Karakida | first6 = O. | last7 = Imai | first7 = S. | last8 = Sakai | first8 = F. | last9 = Imai | first9 = Y. | title = Giant cell tumors of bone containing large amounts of hemosiderin: MR-pathologic correlation. | journal = J Comput Assist Tomogr | volume = 15 | issue = 6 | pages = 1024-7 | month = | year = | doi = | PMID = 1939753 }}</ref><ref name=pmid18554912>{{Cite journal | last1 = Matsushige | first1 = T. | last2 = Nakaoka | first2 = M. | last3 = Yahara | first3 = K. | last4 = Kagawa | first4 = K. | last5 = Miura | first5 = H. | last6 = Ohnuma | first6 = H. | last7 = Kurisu | first7 = K. | title = Giant cell tumor of the temporal bone with intratumoral hemorrhage. | journal = J Clin Neurosci | volume = 15 | issue = 8 | pages = 923-7 | month = Aug | year = 2008 | doi = 10.1016/j.jocn.2007.03.013 | PMID = 18554912 }}</ref> | |||
Notes: | |||
*Giant cells typically present in abundance. | |||
DDx: | |||
*[[Giant cell lesions]]. | |||
**[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells. | |||
===Images=== | |||
<gallery> | |||
Image:Giant_cell_tumour_of_bone_-_low_mag.jpg | GCT of bone - low mag. (WC) | |||
Image:Giant cell tumour of bone - intermed mag.jpg | GCT of bone - intermed. mag. (WC) | |||
Image:Giant_cell_tumour_of_bone_-_high_mag.jpg | GCT of bone - high mag. (WC) | |||
Image:Giant cell tumour of bone - very high mag.jpg | GCT of bone - very high mag. (WC) | |||
</gallery> | |||
==IHC== | |||
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref> | |||
**This seems to be contradicted by another paper.<ref name=pmid20012988>{{cite journal |author=Alberghini M, Kliskey K, Krenacs T, ''et al.'' |title=Morphological and immunophenotypic features of primary and metastatic giant cell tumour of bone |journal=Virchows Arch. |volume=456 |issue=1 |pages=97–103 |year=2010 |month=January |pmid=20012988 |doi=10.1007/s00428-009-0863-2 |url=}}</ref> | |||
==See also== | |||
*[[Bone]]. | |||
*[[Chondro-osseous tumours]]. | |||
*[[Giant cells]]. | |||
*[[Giant cell lesions]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | |||
[[Category:Chondro-osseous tumours]] | |||