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Difference between revisions of "Forensic pathology"
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→Toxicology & biochemistry
m (→Hypothermia: +link, DDx) |
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*Serotonin syndrome. | *Serotonin syndrome. | ||
===Ethanol=== | ===Toxicology=== | ||
*Should be submitted with anatomical findings and history. | |||
Common submissions: | |||
#Alcohol only. | |||
#Suspected toxicologic death - need details on drugs. | |||
====Mandated by case<ref>{{Ref OPMfP|14}}</ref>==== | |||
*Sudden death in children under five years old. | |||
*Workplace deaths. | |||
*Fatal motor vehicle collision. | |||
*Aviationi deaths. | |||
*Fire-related deaths (carboxyhemoglobin). | |||
====Ethanol==== | |||
*Usually measure in Canada: ''mass of EtOH (mg)/volume of blood (mL)''. | *Usually measure in Canada: ''mass of EtOH (mg)/volume of blood (mL)''. | ||
**Limit (Ontario): 80 milligrams of alcohol in 100 millilitres of blood (0.08).<ref>URL: [http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml]. Accessed on: 28 September 2010.</ref> | **Limit (Ontario): 80 milligrams of alcohol in 100 millilitres of blood (0.08).<ref>URL: [http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml http://www.mto.gov.on.ca/english/safety/impaired/fact-sheet.shtml]. Accessed on: 28 September 2010.</ref> | ||
===Cocaine=== | ====Cocaine==== | ||
*No agreed upon toxic dose<ref name=pmid15075681>{{cite journal |author=Stephens BG, Jentzen JM, Karch S, Wetli CV, Mash DC |title=National Association of Medical Examiners position paper on the certification of cocaine-related deaths |journal=Am J Forensic Med Pathol |volume=25 |issue=1 |pages=11–3 |year=2004 |month=March |pmid=15075681 |doi= |url=}}</ref> - due to tolerance. | *No agreed upon toxic dose<ref name=pmid15075681>{{cite journal |author=Stephens BG, Jentzen JM, Karch S, Wetli CV, Mash DC |title=National Association of Medical Examiners position paper on the certification of cocaine-related deaths |journal=Am J Forensic Med Pathol |volume=25 |issue=1 |pages=11–3 |year=2004 |month=March |pmid=15075681 |doi= |url=}}</ref> - due to tolerance. | ||
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*+/-Cardiac hypertrophy. | *+/-Cardiac hypertrophy. | ||
===Ethylene glycol=== | ====Ethylene glycol==== | ||
*Not done in routine toxicology screening. | *Not done in routine toxicology screening. | ||
*Birefringent calcium oxalate crystals found in kidney (with polarized light).<ref name=Ref_KFP589>{{Ref KFP|589}}</ref> | *Birefringent calcium oxalate crystals found in kidney (with polarized light).<ref name=Ref_KFP589>{{Ref KFP|589}}</ref> | ||
===Anaphylaxis=== | ====Anaphylaxis==== | ||
Serology:<ref name=pmid20176258>{{cite journal |author=Simons FE |title=Anaphylaxis |journal=J. Allergy Clin. Immunol. |volume=125 |issue=2 Suppl 2 |pages=S161–81 |year=2010 |month=February |pmid=20176258 |doi=10.1016/j.jaci.2009.12.981 |url=}}</ref> | Serology:<ref name=pmid20176258>{{cite journal |author=Simons FE |title=Anaphylaxis |journal=J. Allergy Clin. Immunol. |volume=125 |issue=2 Suppl 2 |pages=S161–81 |year=2010 |month=February |pmid=20176258 |doi=10.1016/j.jaci.2009.12.981 |url=}}</ref> | ||
*IgE. | *IgE. | ||