Difference between revisions of "Common variable immunodeficiency"

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Common variable immunodeficiency (view source)

Revision as of 04:50, 7 March 2013

127 bytes removed ,  04:50, 7 March 2013
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*[[Graft versus host disease]].
*[[Graft versus host disease]].


===Esophagus===
Features by site in the GI tract:<ref name=pmid18043034>{{Cite journal  | last1 = Daniels | first1 = JA. | last2 = Lederman | first2 = HM. | last3 = Maitra | first3 = A. | last4 = Montgomery | first4 = EA. | title = Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1800-12 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e3180cab60c | PMID = 18043034 }}</ref>
Features - esophagus:<ref name=pmid18043034>{{Cite journal  | last1 = Daniels | first1 = JA. | last2 = Lederman | first2 = HM. | last3 = Maitra | first3 = A. | last4 = Montgomery | first4 = EA. | title = Gastrointestinal tract pathology in patients with common variable immunodeficiency (CVID): a clinicopathologic study and review. | journal = Am J Surg Pathol | volume = 31 | issue = 12 | pages = 1800-12 | month = Dec | year = 2007 | doi = 10.1097/PAS.0b013e3180cab60c | PMID = 18043034 }}</ref>
{| class="wikitable sortable"
*Intraepithelial PMNs & candida.
!Site
*+/-Abundant intraepithelial lymphocytes.
!Features
 
|-
===Stomach===
| Esophagus
Features - stomach:<ref name=pmid18043034/>
| intraepithelial PMNs & candida +/-abundant intraepithelial lymphocytes
*Lack of [[plasma cell]]s ~ 2/3 of individuals - '''key feature'''
|-
*Lymphoid aggregates - common.
| Stomach
*+/-[[Lymphocytic gastritis]].
| lack of [[plasma cell]]s (~2/3 of individuals), lymphoid aggregates (common), +/-[[lymphocytic gastritis]], +/-intraepithelial neutrophils, +/-infections ([[CMV]], [[H. pylori]], [[cryptosporidium]])
*+/-Intraepithelial neutrophils.
|-
*+/-Infections ([[CMV]], [[H. pylori]], [[cryptosporidium]]).
| Small bowel
 
| villous blunting (>80% of individuals), decreased plasma cells (~2/3 of individuals), lymphoid aggregates (~1/2 of individuals), +/-neutrophils + infections (CMV, cryptosporidium)
===Small bowel===
|-
Features - small bowel:<ref name=pmid18043034/>
| Large bowel
*Villous blunting > 80% of individuals.
| decreased plasma cells, lymphoid aggregates, +/-apparent apoptosis
*Decreased plasma cells ~ 2/3 of individuals - '''key feature'''.
|}
*Lymphoid aggregates ~ 1/2 of individuals.
*+/-Neutrophils + infections (CMV, cryptosporidium).
 
===Large bowel===
Features:<ref name=pmid18043034/>
*Decreased plasma cells - '''key feature'''.
*Lymphoid aggregates.
*+/-Apparent apoptosis.


==See also==
==See also==
Michael
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