Difference between revisions of "Small cell carcinoma"
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(+hypercalcemic type small cell carincoma) |
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'''Small cell carcinoma''' is a type of carcinoma. It is mostly commonly from the [[lung tumours|lung]] ~95% of cases.<ref name=pmid21618245/> | '''Small cell carcinoma''' is a type of carcinoma. It is mostly commonly from the [[lung tumours|lung]] ~95% of cases.<ref name=pmid21618245/> | ||
=Overview= | |||
===Grouping=== | ===Grouping=== | ||
May be grouped as:<ref name=pmid21618245>{{Cite journal | last1 = Grossman | first1 = RA. | last2 = Pedroso | first2 = FE. | last3 = Byrne | first3 = MM. | last4 = Koniaris | first4 = LG. | last5 = Misra | first5 = S. | title = Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? | journal = J Surg Oncol | volume = | issue = | pages = | month = May | year = 2011 | doi = 10.1002/jso.21976 | PMID = 21618245 }}</ref> | May be grouped as:<ref name=pmid21618245>{{Cite journal | last1 = Grossman | first1 = RA. | last2 = Pedroso | first2 = FE. | last3 = Byrne | first3 = MM. | last4 = Koniaris | first4 = LG. | last5 = Misra | first5 = S. | title = Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers? | journal = J Surg Oncol | volume = | issue = | pages = | month = May | year = 2011 | doi = 10.1002/jso.21976 | PMID = 21618245 }}</ref> | ||
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*Thyroid gland.<ref name=pmid21644012>{{Cite journal | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume = | issue = | pages = | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref> | *Thyroid gland.<ref name=pmid21644012>{{Cite journal | last1 = Beach | first1 = DF. | last2 = Klump | first2 = WJ. | last3 = Haddad | first3 = G. | last4 = Reid | first4 = LM. | last5 = Schwarting | first5 = R. | last6 = Hageboutros | first6 = A. | title = Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland. | journal = Med Oncol | volume = | issue = | pages = | month = Jun | year = 2011 | doi = 10.1007/s12032-011-9996-7 | PMID = 21644012 }}</ref> | ||
=General= | |||
Classic tumour with paraneoplastic syndromes - may be associated with:<ref name=pmid18316005>{{Cite journal | last1 = Sher | first1 = T. | last2 = Dy | first2 = GK. | last3 = Adjei | first3 = AA. | title = Small cell lung cancer. | journal = Mayo Clin Proc | volume = 83 | issue = 3 | pages = 355-67 | month = Mar | year = 2008 | doi = | PMID = 18316005 }}</ref> | Classic tumour with paraneoplastic syndromes - may be associated with:<ref name=pmid18316005>{{Cite journal | last1 = Sher | first1 = T. | last2 = Dy | first2 = GK. | last3 = Adjei | first3 = AA. | title = Small cell lung cancer. | journal = Mayo Clin Proc | volume = 83 | issue = 3 | pages = 355-67 | month = Mar | year = 2008 | doi = | PMID = 18316005 }}</ref> | ||
*Syndrome of inappropriate antidiuretic hormone secretion (SIADH). | *Syndrome of inappropriate antidiuretic hormone secretion (SIADH). | ||
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*Lambert-Eaton myasthenic syndrome. | *Lambert-Eaton myasthenic syndrome. | ||
=Microscopic= | |||
Features: | Features: | ||
*Small cells -- typically 15-20 micrometers ~ 2x the size of [[RBC]]. | *Small cells -- typically 15-20 micrometers ~ 2x the size of [[RBC]]. | ||
| Line 37: | Line 37: | ||
*[[Small round cell tumours]]. | *[[Small round cell tumours]]. | ||
*[[Chloroma]]. | *[[Chloroma]]. | ||
=Special types= | |||
==Ovarian small cell carcinoma of the hypercalcemic type== | |||
*[[AKA]] ''small cell carcinoma, hypercalcemic type''. | |||
===General=== | |||
*Hypercalcemia.<ref name=pmid7943531>{{Cite journal | last1 = Young | first1 = RH. | last2 = Oliva | first2 = E. | last3 = Scully | first3 = RE. | title = Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases. | journal = Am J Surg Pathol | volume = 18 | issue = 11 | pages = 1102-16 | month = Nov | year = 1994 | doi = | PMID = 7943531 }}</ref> | |||
*Rare. | |||
===Microscopic=== | |||
Features:<ref name=pmid7943531/> | |||
*Small cell carcinoma. | |||
*Follicle-like spaces. | |||
==See also== | ==See also== | ||
Revision as of 22:28, 12 December 2011
Small cell carcinoma is a type of carcinoma. It is mostly commonly from the lung ~95% of cases.[1]
Overview
Grouping
May be grouped as:[1]
- Pulmonary.
- Gastrointestinal.
- Genitourinary.
- Head & neck.
- Breast.
- Other.
Sites other than lung
General
Classic tumour with paraneoplastic syndromes - may be associated with:[4]
- Syndrome of inappropriate antidiuretic hormone secretion (SIADH).
- Clinical: hyponatremia.
- Paraneoplastic cerebellar degeneration.
- Lambert-Eaton myasthenic syndrome.
Microscopic
Features:
- Small cells -- typically 15-20 micrometers ~ 2x the size of RBC.
- Scant cytoplasm.
- Stippled chromatin.
- +/-Nuclear moulding.
Images:
- Small cell carcinoma - cytology (WC).
- Metastatic small cell carcinoma - high mag. (WC).
- Metastatic small cell carcinoma - very high mag. (WC).
DDx:
Special types
Ovarian small cell carcinoma of the hypercalcemic type
- AKA small cell carcinoma, hypercalcemic type.
General
- Hypercalcemia.[5]
- Rare.
Microscopic
Features:[5]
- Small cell carcinoma.
- Follicle-like spaces.
See also
- Lung tumours.
- Azzopardi phenomenon.
- Chloroma (AKA granulocytic sarcoma, myeloid sarcoma).
References
- ↑ 1.0 1.1 Grossman, RA.; Pedroso, FE.; Byrne, MM.; Koniaris, LG.; Misra, S. (May 2011). "Does surgery or radiation therapy impact survival for patients with extrapulmonary small cell cancers?". J Surg Oncol. doi:10.1002/jso.21976. PMID 21618245.
- ↑ Cesaretti, M.; Guarnieri, A.; Gaggelli, I.; Tirone, A.; Francioli, N.; Carli, AF.. "Small cell carcinoma of the breast. Report of a case.". Ann Ital Chir 82 (1): 61-4. PMID 21657157.
- ↑ Beach, DF.; Klump, WJ.; Haddad, G.; Reid, LM.; Schwarting, R.; Hageboutros, A. (Jun 2011). "Extrapulmonary small cell: a novel case of small cell carcinoma of the thyroid gland.". Med Oncol. doi:10.1007/s12032-011-9996-7. PMID 21644012.
- ↑ Sher, T.; Dy, GK.; Adjei, AA. (Mar 2008). "Small cell lung cancer.". Mayo Clin Proc 83 (3): 355-67. PMID 18316005.
- ↑ 5.0 5.1 Young, RH.; Oliva, E.; Scully, RE. (Nov 1994). "Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathological analysis of 150 cases.". Am J Surg Pathol 18 (11): 1102-16. PMID 7943531.