Urothelial carcinoma-like prostatic carcinoma
Urothelial carcinoma-like prostatic carcinoma, abbreviated UCLPC, is a prostatic carcinoma that histologically mimics urothelial carcinoma.
It is not a formally recognized type of prostate cancer.
Prostatic carcinoma with pseudopapillae and prostatic adenocarcinoma with pseudopapillae redirect here.
General
- Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
- Relative proximity of the urinary bladder and prostate results in clinical scenarios where the primary site is not readily apparent.
Clinical:
- History of urothelial carcinoma lacking.
- +/-Elevated PSA.
Gross
Classic tumour locations:
- Bladder neck.
- Trigone/base of bladder.
- Prostatic urethra.
Microscopic
Features:
- Large epithelioid cells with prominent nucleoli and (usually) moderate nuclear pleomorphism.
- +/-Papillary structures (pseudopapillae).[1]
- +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.
DDx:
- Urothelial carcinoma.
- Collision tumour consisting of urothelial carcinoma and prostatic carcinoma.
- Other carcinomas.
Images
UCLPC - very low mag.
UCLPC - low mag.
UCLPC - low mag.
UCLPC - intermed. mag.
UCLPC - intermed. mag.
UCLPC - high mag.
UCLPC - high mag.
UCLPC - very high mag.
UCLPC - very high mag.
PC - intermed. mag.
PC - high mag.
IHC
Features:[1]
- GATA3 -ve.
- NKX3.1 +ve.
Images
UCLPC - NKX3.1 - intermed. mag.
UCLPC - AMACR-CK5/6 - very low mag.
UCLPC - AMACR-CK5/6 - intermed. mag.
UCLPC - GATA3 - intermed. mag.
Urothelium - GATA3 - high mag.
