Urothelial carcinoma-like prostatic carcinoma
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It is not a formally recognized type of prostate cancer.
Prostatic carcinoma with pseudopapillae and prostatic adenocarcinoma with pseudopapillae redirect here.
- Histologic features of high grade urothelial carcinomas and high grade prostatic carcinomas overlap.
- Relative proximity of the urinary bladder and prostate results in clinical scenarios where the primary site is not readily apparent.
- History of urothelial carcinoma lacking.
- +/-Elevated PSA.
Classic tumour locations:
- Bladder neck.
- Trigone/base of bladder.
- Prostatic urethra.
- Large epithelioid cells with prominent nucleoli and (usually) moderate nuclear pleomorphism.
- +/-Papillary structures (pseudopapillae).
- +/-Features suggestive of prostatic carcinoma - cribriforming glands or poorly formed glandular structures.
- Urothelial carcinoma.
- Collision tumour consisting of urothelial carcinoma and prostatic carcinoma.
- Other carcinomas.
- GATA3 -ve.
- NKX3.1 +ve.