Talk:Programmed death-ligand 1
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Urothelial carcinoma
Urothelial carcinoma - atezolizumab[1]
Renal cell carcinoma
- 2015 paper: ~ 15% respond to PD-L1[1]
- Biomarkers predict response
- 2018 paper: ~ 70% durable response among those that discontinue d/t side effects[2]
- 2018 paper: response rates are low in UCC and RCC, current PD-L1 tests not useful in UCC and RCC[3]
- 2018 meta-analysis: PD-L1 is a poor prognosticator in RCC (HR~2.76)[4]
CPS and TPS
CPS in lymph nodes:
- H&N: https://pubmed.ncbi.nlm.nih.gov/35420378/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7413953/
- H&N cytology: https://pmc.ncbi.nlm.nih.gov/articles/PMC8810615/
- Breast: https://pmc.ncbi.nlm.nih.gov/articles/PMC10078903/ https://surgexppathol.biomedcentral.com/articles/10.1186/s42047-019-0033-z
References
- ↑ Rosenberg, JE.; Hoffman-Censits, J.; Powles, T.; van der Heijden, MS.; Balar, AV.; Necchi, A.; Dawson, N.; O'Donnell, PH. et al. (May 2016). "Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial.". Lancet 387 (10031): 1909-20. doi:10.1016/S0140-6736(16)00561-4. PMID 26952546.