Talk:Langerhans cell histiocytosis

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Microscopic description

The sections show morphologically normal bone, associated with abundant eosinophils and large cells with abundant foamy cytoplasm, fine granular chromatin, and nuclei with a kidney bean-like and a coffee bean-like morphology, due to folding of the nuclear membrane (Langerhans histiocytes). The Langerhans histiocytes show strong membranous immunostaining with CD68 and CD1a, and strong nuclear immunostaining with S100. Electronmicroscopy shows electron dense tenis racket-shaped cytoplasmic inclusions (Birbeck granules).

Final diagnosis

A. Bone, site not specified, biopsy - Langerhans cell histiocytosis.