Difference between revisions of "Medical kidney diseases"

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Medical kidney diseases (view source)

Revision as of 02:41, 23 November 2011

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→‎Rare diseases: re-arr
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Note:
Note:
*Normal GBM: 300-350 nm.
*Normal GBM: 300-350 nm.
==Alport syndrome==
===General===
Clinical:
*Hearing loss (sensorineural).
*Hematuria - usually preceeds hearing loss.<ref name=emedicine981126>URL: [http://emedicine.medscape.com/article/981126-overview http://emedicine.medscape.com/article/981126-overview]</ref>
*Can be thought of a pathologic form of ''[[thin basement membrane disease]]''.<ref>AM. 13 August 2009.</ref>
Etiology:
*Genetic defect - collagen type IV.
Inheritance:<ref name=emedicine981126/>
*X-linked - 80%.
*Autosomal recessive - 15%.
*Autosomal dominant - 5%.
===Microscopic===
Features:<ref name=pmid9727383/>
*Normal.
===IF===
*Negative.
===EM===
Features:<ref name=pmid9727383>{{Cite journal  | last1 = Kashtan | first1 = CE. | title = Alport syndrome and thin glomerular basement membrane disease. | journal = J Am Soc Nephrol | volume = 9 | issue = 9 | pages = 1736-50 | month = Sep | year = 1998 | doi =  | PMID = 9727383 | url=http://jasn.asnjournals.org/content/9/9/1736.long}}</ref>
*Abnormal glomerular basement membrane (GBM); thinning or thickening.
**Classically thinning with thick lamellation (splitting/multi-layering).


==Idiopathic nodular glomerulosclerosis==
==Idiopathic nodular glomerulosclerosis==
Line 788: Line 817:
**Aminoglycosides,  
**Aminoglycosides,  
**Chloroquine.
**Chloroquine.
==Alport syndrome==
===General===
Clinical:
*Hearing loss (sensorineural).
*Hematuria - usually preceeds hearing loss.<ref name=emedicine981126>URL: [http://emedicine.medscape.com/article/981126-overview http://emedicine.medscape.com/article/981126-overview]</ref>
*Can be thought of a pathologic form of ''[[thin basement membrane disease]]''.<ref>AM. 13 August 2009.</ref>
Etiology:
*Genetic defect - collagen type IV.
Inheritance:<ref name=emedicine981126/>
*X-linked - 80%.
*Autosomal recessive - 15%.
*Autosomal dominant - 5%.
===Microscopic===
Features:<ref name=pmid9727383/>
*Normal.
===IF===
*Negative.
===EM===
Features:<ref name=pmid9727383>{{Cite journal  | last1 = Kashtan | first1 = CE. | title = Alport syndrome and thin glomerular basement membrane disease. | journal = J Am Soc Nephrol | volume = 9 | issue = 9 | pages = 1736-50 | month = Sep | year = 1998 | doi =  | PMID = 9727383 | url=http://jasn.asnjournals.org/content/9/9/1736.long}}</ref>
*Abnormal glomerular basement membrane (GBM); thinning or thickening.
**Classically thinning with thick lamellation (splitting/multi-layering).


==Myeloma==
==Myeloma==
Michael
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