Difference between revisions of "Medical liver disease"

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Medical liver disease (view source)

Revision as of 18:16, 21 November 2011

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*Primary biliary cirrhosis without granulomas.
*Primary biliary cirrhosis without granulomas.
*Drug reaction.
*Drug reaction.
=Other=
==Congestive hepatopathy==
===General===
*Liver failure due to (right) heart failure.
*AKA ''cardiac cirrhosis'' - a term used by clinicians.
**Generally, it does not satisfy pathologic criteria for cirrhosis.<ref>URL: [http://emedicine.medscape.com/article/151792-overview http://emedicine.medscape.com/article/151792-overview]. Accessed on: 17 June 2010.</ref>
===Gross===
*"Nutmeg" liver - yellow spotted appearance.
===Microscopic===
Features:<ref>URL: [http://emedicine.medscape.com/article/151792-diagnosis http://emedicine.medscape.com/article/151792-diagnosis]. Accessed on: 17 June 2010.</ref>
*Zone III atrophy.
*Portal venule (central vein) distension.
*Perisinusoidal fibrosis - progresses to centrilobular fibrosis and then diffuse fibrosis.
*Dilation of sinusoids in ''all'' zone III areas - '''key feature'''.<ref>Suggested by OA. September 2009.</ref>
Image: [http://commons.wikimedia.org/wiki/File:Congestive_hepatopathy_high_mag.jpg Congestive hepatopathy (WC)].


=Metabolic and toxic=
=Metabolic and toxic=
Line 409: Line 390:
*IHC for A1-AT exists - but isn't useful according to one paper.<Ref name=pmid3512609>{{Cite journal  | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi =  | PMID = 3512609 }}</ref>
*IHC for A1-AT exists - but isn't useful according to one paper.<Ref name=pmid3512609>{{Cite journal  | last1 = Theaker | first1 = JM. | last2 = Fleming | first2 = KA. | title = Alpha-1-antitrypsin and the liver: a routine immunohistological screen. | journal = J Clin Pathol | volume = 39 | issue = 1 | pages = 58-62 | month = Jan | year = 1986 | doi =  | PMID = 3512609 }}</ref>
**Blood serum values used. (???)
**Blood serum values used. (???)
=Other=
==Congestive hepatopathy==
===General===
*Liver failure due to (right) heart failure.
*AKA ''cardiac cirrhosis'' - a term used by clinicians.
**Generally, it does not satisfy pathologic criteria for cirrhosis.<ref>URL: [http://emedicine.medscape.com/article/151792-overview http://emedicine.medscape.com/article/151792-overview]. Accessed on: 17 June 2010.</ref>
===Gross===
*"Nutmeg" liver - yellow spotted appearance.
===Microscopic===
Features:<ref>URL: [http://emedicine.medscape.com/article/151792-diagnosis http://emedicine.medscape.com/article/151792-diagnosis]. Accessed on: 17 June 2010.</ref>
*Zone III atrophy.
*Portal venule (central vein) distension.
*Perisinusoidal fibrosis - progresses to centrilobular fibrosis and then diffuse fibrosis.
*Dilation of sinusoids in ''all'' zone III areas - '''key feature'''.<ref>Suggested by OA. September 2009.</ref>
Image: [http://commons.wikimedia.org/wiki/File:Congestive_hepatopathy_high_mag.jpg Congestive hepatopathy (WC)].


==Drug toxicity==
==Drug toxicity==
Michael
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